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儿童非酒精性脂肪性肝病中肝脏脂质代谢的改变及其与膳食常量营养素的关系。

Alterations in Hepatic Lipid Metabolism, and their Relation to Dietary Macronutrients in Pediatric Nonalcoholic Fatty Liver Disease.

作者信息

St-Jules David E, Watters Corilee A

机构信息

Harvard School of Public Health, Department of Nutrition, 665 Huntington Avenue, Boston MA, USA, 02119.

出版信息

Drug Metab Lett. 2015;9(2):72-9. doi: 10.2174/1872312809666150907115208.

DOI:10.2174/1872312809666150907115208
PMID:26343136
Abstract

Nonacoholic fatty liver disease (NAFLD) is a common complication of pediatric obesity in which diet is a major factor in causation and the cornerstone of treatment. In this review, the alterations in hepatic lipid metabolism that contribute to pediatric NAFLD, and impact of dietary proteins, carbohydrates, and fats on hepatic fat metabolism and NAFLD are described. Lastly, dietary recommendations for achieving changes in macronutrient intakes that can be beneficial in the treatment of NAFLD are provided.

摘要

非酒精性脂肪性肝病(NAFLD)是小儿肥胖的常见并发症,饮食是其发病的主要因素和治疗的基石。在本综述中,描述了导致小儿NAFLD的肝脏脂质代谢变化,以及膳食蛋白质、碳水化合物和脂肪对肝脏脂肪代谢和NAFLD的影响。最后,提供了关于实现宏量营养素摄入量变化的膳食建议,这些变化可能有助于NAFLD的治疗。

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