Delaleau Mildred, Borden Katherine L B
Department of Pathology and Cell Biology, Institute for Research in Immunology and Cancer, Université de Montréal, Montréal, QC, H3C 3J7, Canada.
Cells. 2015 Aug 28;4(3):452-73. doi: 10.3390/cells4030452.
Nuclear mRNA export plays an important role in gene expression. We describe the mechanisms of mRNA export including the importance of mRNP assembly, docking with the nuclear basket of the nuclear pore complex (NPC), transit through the central channel of the NPC and cytoplasmic release. We describe multiple mechanisms of mRNA export including NXF1 and CRM1 mediated pathways. Selective groups of mRNAs can be preferentially transported in order to respond to cellular stimuli. RNAs can be selected based on the presence of specific cis-acting RNA elements and binding of specific adaptor proteins. The role that dysregulation of this process plays in human disease is also discussed.
核mRNA输出在基因表达中起重要作用。我们描述了mRNA输出的机制，包括mRNP组装、与核孔复合体（NPC）的核篮对接、通过NPC中央通道的转运以及细胞质释放的重要性。我们描述了多种mRNA输出机制，包括NXF1和CRM1介导的途径。为了响应细胞刺激，特定的mRNA群体可以被优先转运。RNA可以根据特定顺式作用RNA元件的存在和特定衔接蛋白的结合来进行选择。我们还讨论了这一过程的失调在人类疾病中所起的作用。
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