Sfaxi Ines, Ben Saad Helmi, Rouatbi Sonia
Laboratory of Physiology, Faculty of Medicine of Sousse, University of Sousse, 4000 Sousse, Tunisia; Department of Physiology and Functional Explorations, Farhat HACHED Hospital, Sousse, Tunisia.
Laboratory of Physiology, Faculty of Medicine of Sousse, University of Sousse, 4000 Sousse, Tunisia; Department of Physiology and Functional Explorations, Farhat HACHED Hospital, Sousse, Tunisia; Research Laboratory N° LR14ES05: Interactions of the Cardiopulmonary System, Faculty of Medicine of Sousse, University of Sousse, Tunisia.
Nitric Oxide. 2015 Nov 15;50:88-97. doi: 10.1016/j.niox.2015.08.008. Epub 2015 Sep 5.
Exhaled-fraction-of-nitric-oxide (Fe) norms are absent in healthy elderly North-African subjects.
i) to identify Fe influencing factors of elderly Tunisians older 50 years and more; ii) to assess the applicability of some published Fe norms for elderly in local population; iii) to set-up Fe norms and to prospectively evaluate their validity in two elderly validation-groups (healthy and asthmatic subjects).
A convenience sample of healthy and asthmatic elderly Tunisians was recruited. Subjects responded to a medical questionnaire and then Fe levels were measured by an online method (Medisoft, Sorinnes (Dinant), Belgium). Clinical, anthropometric and spirometric data were collected. Three groups of subjects were identified: group I (healthy-elderly; n = 100, 57 females); group II (healthy-validation; n = 17, 4 females) and group III (asthmatic-validation; n = 10, 9 females). ANOVA was performed to compare the three groups' data.
No significant factor, among those evaluated, influenced Tunisian elderly Fe values. The available published Fe norms did not reliably predict Fe in Tunisian elderly population. The mean ± SD (minimum-maximum) of Fe (ppb) for group I was 14 ± 6 (3-34). For Tunisian people, each elderly Fe value higher than 34 ppb will be considered as abnormal. There was no statistical significant difference between Fe (ppb) mean values of group I and groups II (15 ± 8) or III (18 ± 13). No subject of group II had a Fe value higher than 34 ppb. Thirty percent of group III subjects had a Fe value higher than 34 ppb.
In practice, Fe value of more than 34 ppb is considered abnormal in elderly Tunisian population.
健康的北非老年受试者中不存在呼出一氧化氮分数（Fe）的标准值。
i）确定影响50岁及以上突尼斯老年人Fe的因素；ii）评估一些已发表的老年人Fe标准值在当地人群中的适用性；iii）建立Fe标准值并前瞻性评估其在两个老年验证组（健康和哮喘受试者）中的有效性。
招募了健康和哮喘的突尼斯老年受试者的便利样本。受试者回答了一份医学问卷，然后通过在线方法（Medisoft，索林斯（迪南特），比利时）测量Fe水平。收集了临床、人体测量和肺功能数据。确定了三组受试者：第一组（健康老年人；n = 100，57名女性）；第二组（健康验证组；n = 17，4名女性）和第三组（哮喘验证组；n = 10，9名女性）。进行方差分析以比较三组数据。
在评估的因素中，没有显著因素影响突尼斯老年人的Fe值。现有的已发表的Fe标准值不能可靠地预测突尼斯老年人群中的Fe值。第一组Fe（ppb）的平均值±标准差（最小值 - 最大值）为14 ± 6（3 - 34）。对于突尼斯人，每个老年人的Fe值高于34 ppb将被视为异常。第一组与第二组（15 ± 8）或第三组（18 ± 13）的Fe（ppb）平均值之间没有统计学显著差异。第二组没有受试者的Fe值高于34 ppb。第三组30%的受试者Fe值高于34 ppb。
在实践中，突尼斯老年人群中Fe值超过34 ppb被认为是异常的。
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