多种官能化的2,2-二取代氧杂环丁烷的合成：新化学空间中的片段基序
Synthesis of diversely functionalised 2,2-disubstituted oxetanes: fragment motifs in new chemical space.
作者信息
Davis Owen A, Croft Rosemary A, Bull James A
机构信息
Department of Chemistry, Imperial College London, South Kensington, London SW7 2AZ, UK.
出版信息
Chem Commun (Camb). 2015 Oct 28;51(84):15446-9. doi: 10.1039/c5cc05740j.
PMID:26344367
Abstract
Di-, tri- and tetra-substituted oxetane derivatives with combinations of ester, amide, nitrile, aryl, sulfone and phosphonate substituents are prepared as fragments or building blocks for drug discovery. The synthesis of these novel oxetane functional groups, in new chemical space, is achieved via rhodium-catalysed O-H insertion and C-C bond forming cyclisation.
摘要
制备具有酯、酰胺、腈、芳基、砜和膦酸酯取代基组合的二取代、三取代和四取代氧杂环丁烷衍生物，作为药物发现的片段或构建模块。这些新型氧杂环丁烷官能团在新的化学空间中的合成是通过铑催化的O-H插入和C-C键形成环化实现的。
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