酒石酸美托洛尔片中新杂质的鉴定、合成、分离与表征
Identification, synthesis, isolation and characterization of new impurity in metoprolol tartrate tablets.
作者信息
Reddy R Buchi, More Kishor R, Gupta Leena, Jha Mukesh S, Magar Laki
机构信息
Ipca Laboratories Ltd., Chemical Research Division, Kandivali Industrial Estate, Kandivali (W). Mumbai 400067, India.
Ipca Laboratories Ltd., Chemical Research Division, Kandivali Industrial Estate, Kandivali (W). Mumbai 400067, India.
出版信息
J Pharm Biomed Anal. 2016 Jan 5;117:104-8. doi: 10.1016/j.jpba.2015.08.039. Epub 2015 Aug 30.
A new unknown impurity was observed in accelerated stability studies of Metoprolol tartrate tablets. This impurity has been identified, synthesized and characterized through different spectral studies and confirmed as an adduct of lactose and Metoprolol formed by Maillard reaction.
在酒石酸美托洛尔片的加速稳定性研究中观察到一种新的未知杂质。已通过不同的光谱研究对该杂质进行了鉴定、合成和表征，并确认为乳糖与美托洛尔通过美拉德反应形成的加合物。
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