Wang Mengmeng, Lyu Zhonglin, Chen Gaojian, Wang Hongwei, Yuan Yuqi, Ding Kaiguo, Yu Qian, Yuan Lin, Chen Hong
College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123, China.
Chem Commun (Camb). 2015 Oct 28;51(84):15434-7. doi: 10.1039/c5cc06944k.
A new strategy for the fabrication of glycosaminoglycan (GAG) analogs was proposed by copolymerizing the sulfonated unit and the glyco unit, 'splitted' from the sulfated saccharide building blocks of GAGs. The synthetic polymers can promote cell proliferation and neural differentiation of embryonic stem cells with the effects even better than those of heparin.
通过将从糖胺聚糖（GAG）的硫酸化糖基构建块中“拆分”出来的磺化单元和糖基单元进行共聚，提出了一种制备GAG类似物的新策略。合成聚合物可以促进胚胎干细胞的细胞增殖和神经分化，其效果甚至优于肝素。
