Tohfafarosh Mariya, Baykal Doruk, Kiel Jonathan W, Mansmann Kevin, Kurtz Steven M
School of Biomedical Engineering, Science and Health Systems, Drexel University, 3401 Market St, Suite 345, Philadelphia, PA, USA.
Exponent, Inc., 3440 Market St, Philadelphia, PA, USA.
J Mech Behav Biomed Mater. 2016 Jan;53:250-256. doi: 10.1016/j.jmbbm.2015.08.024. Epub 2015 Aug 24.
Hydrogels are known to possess cartilage-like mechanical and lubrication properties; however, hydrogel sterilization is challenging. Cyborgel(™), a proprietary hydrogel, is intended for use as a cartilage replacement implant. This study evaluated the effect of 30-35 kGy e-beam and gamma radiation on the polymer swell ratio, and the mechanical, chemical and tribological behavior of this hydrogel. Three different formulations were mechanically tested, and material parameters were identified using finite element analysis. FTIR spectroscopy was used to investigate chemical changes. Wear test was carried out for 2 million cycles in bovine serum, followed by 2 million cycles in distilled water. No significant difference was found in the swell ratio, mechanical and tribological properties of control hydrogel samples and those exposed to e-beam or gamma radiation; however, chemical spectra of e-beam sterilized samples revealed minor changes, which were absent in unsterilized and gamma sterilized samples.
水凝胶具有类似软骨的机械和润滑特性；然而，水凝胶的灭菌具有挑战性。Cyborgel™（一种专利水凝胶）旨在用作软骨替代植入物。本研究评估了30-35 kGy电子束和伽马辐射对该水凝胶的聚合物溶胀率以及机械、化学和摩擦学行为的影响。对三种不同配方进行了力学测试，并使用有限元分析确定了材料参数。采用傅里叶变换红外光谱法研究化学变化。在牛血清中进行200万次循环的磨损试验，然后在蒸馏水中进行200万次循环。对照水凝胶样品与经电子束或伽马辐射处理的样品在溶胀率、机械和摩擦学性能方面未发现显著差异；然而，电子束灭菌样品的化学光谱显示有微小变化，而未灭菌和伽马灭菌样品中不存在这种变化。
