Kim Hyoung-Mi, Park Jae Hong, Choi You Jin, Oh Jae-Min, Park Junghun
Biomedical Manufacturing Technology Center (BMTC), Korea Institute of Industrial Technology (KITECH) Yeongcheon-si Gyeongsangbuk-do 38822 Republic of Korea
Department of Energy and Materials Engineering, Dongguk University-Seoul Seoul 04620 Republic of Korea.
RSC Adv. 2023 Feb 14;13(8):5529-5537. doi: 10.1039/d2ra07276a. eCollection 2023 Feb 6.
Hyaluronic acid (HA) is a natural linear polysaccharide which has been widely used in cosmetics and pharmaceuticals including drug delivery systems because of its excellent biocompatibility. In this study, we investigated the one-pot synthesis of HA-coated gold nanoparticles (AuNP-HA) as a drug delivery carrier. The HAs with different molecular weights were produced by e-beam irradiation and employed as coating materials for AuNPs. Sulfasalazine (SSZ), a poorly water-soluble drug, was used to demonstrate the efficiency of drug delivery and the controlled release behaviour of the AuNP-HA. As the molecular weight of the HA decreased, the drug encapsulation efficiency of the SSZ increased up to 94%, while drug loading capacity of the SSZ was maintained at the level of about 70%. The prepared AuNP-HA-SSZ exhibited slow release of the SSZ over a short time and excellent sensitivity to different pHs and physiological conditions. The SSZ release rate was the lowest in simulated gastric conditions and the highest in simulated intestinal conditions. In this case, the AuNP-HA protects the SSZ from release under the acidic pH conditions in the stomach; on the other hand, the drug release was facilitated in the basic environment of the small intestine and colon. The SSZ was released under simulated intestinal conditions through anomalous drug transport and followed the Korsmeyer-Peppas model. Therefore, this study suggests that AuNP-HA is a promising orally-administered and intestine-targeted drug delivery system with controlled release characteristics.
透明质酸（HA）是一种天然线性多糖，因其优异的生物相容性而被广泛应用于化妆品和制药领域，包括药物递送系统。在本研究中，我们研究了一锅法合成HA包覆的金纳米颗粒（AuNP-HA）作为药物递送载体。通过电子束辐照制备了不同分子量的HA，并将其用作AuNP的包覆材料。使用难溶性药物柳氮磺胺吡啶（SSZ）来证明AuNP-HA的药物递送效率和控释行为。随着HA分子量的降低，SSZ的药物包封率提高至94%，而SSZ的载药量保持在约70%的水平。制备的AuNP-HA-SSZ在短时间内表现出SSZ的缓慢释放，并且对不同的pH值和生理条件具有优异的敏感性。SSZ释放速率在模拟胃液条件下最低，在模拟肠液条件下最高。在这种情况下，AuNP-HA可保护SSZ在胃的酸性pH条件下不释放；另一方面，在小肠和结肠的碱性环境中促进药物释放。SSZ在模拟肠液条件下通过异常药物转运释放，并符合Korsmeyer-Peppas模型。因此，本研究表明AuNP-HA是一种具有控释特性的有前景的口服肠道靶向药物递送系统。
