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给予硫胺素后,低心排血量和血流动力学恶化的急性暴发性脚气病得到显著治疗。

Shoshin Beriberi With Low Cardiac Output and Hemodynamic Deterioration Treated Dramatically by Thiamine Administration.

作者信息

Imamura Teruhiko, Kinugawa Koichiro

机构信息

Department of Therapeutic Strategy for Heart Failure, Graduate School of Medicine, The University of Tokyo.

出版信息

Int Heart J. 2015;56(5):568-70. doi: 10.1536/ihj.15-033. Epub 2015 Sep 4.

Abstract

"Shoshin beriberi", which is a fulminant form of cardiovascular beriberi accompanied by hemodynamic deterioration with high cardiac output and decreased systemic blood pressure, caused by thiamine deficiency due to alcoholic abuse or malnutrition, is often difficult to address because of its rarity and non-specific symptoms. We here present a patient with a history of alcoholic abuse who had suffered hemodynamic deterioration with extremely low cardiac output refractory to extracorporeal membrane oxygenation and intravenous catecholamine support, which was improved dramatically by bolus intravenous thiamine administration. Such a type with low cardiac output would be the most severe form of Shoshin beriberi, and cannot be rescued without diagnostic administration of thiamine.

摘要

“干性脚气病”是一种暴发性心血管型脚气病,伴有高心输出量和全身血压降低的血流动力学恶化,由酒精滥用或营养不良导致的硫胺素缺乏引起,因其罕见性和非特异性症状,往往难以治疗。我们在此报告一名有酒精滥用史的患者,其出现了血流动力学恶化,心输出量极低,对体外膜肺氧合和静脉注射儿茶酚胺支持治疗无效,静脉推注硫胺素后病情显著改善。这种低心输出量类型可能是干性脚气病最严重的形式,若不进行诊断性硫胺素给药则无法救治。

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