Stein A L, Bilheri F N, Zeni G
Laboratório de Síntese, Reatividade, Avaliação Farmacológica e Toxicológica de Organocalcogênios, UFSM, CCNE, Santa Maria, Rio Grande do Sul 97105-900, Brazil.
Chem Commun (Camb). 2015 Nov 4;51(85):15522-5. doi: 10.1039/c5cc06347g.
We reported herein the regio- and stereoselective palladium-catalyzed cross-coupling reactions of unsaturated organoselenides with Sonogashira, Suzuki, Negishi and Kumada partners. The reactions were in general carried out with Pd(PPh3)4 (10 mol%), in DMF at 80 °C to afford the cross-coupling products in good yields. This strategy tolerated a wide range of substrates, such as alkynyl, vinyl, aryl and heteroaryl selenides with a variety of sensitive functional groups and gave the cross-coupling products in good yields.
我们在此报道了不饱和有机硒化物与Sonogashira、Suzuki、Negishi和Kumada反应伙伴之间的区域和立体选择性钯催化交叉偶联反应。这些反应通常在80℃的N,N-二甲基甲酰胺中用四(三苯基膦)钯(10 mol%)进行，以良好的产率得到交叉偶联产物。该策略适用于多种底物，如带有各种敏感官能团的炔基、乙烯基、芳基和杂芳基硒化物，并以良好的产率得到交叉偶联产物。
