Wu Kun, Wu Chuan, Jia Xiao-Ying, Zhou Lin, Li Qing-Han
Key Laboratory of General Chemistry of the National Ethnic Affairs Commission, College of Chemistry and Environment, Southwest Minzu University Chengdu 610041 P. R. China
RSC Adv. 2022 May 3;12(21):13314-13318. doi: 10.1039/d2ra02127g. eCollection 2022 Apr 28.
A highly efficient method for the synthesis of aryl substituted conjugated enediynes and unsymmetrical 1,3-diynes selective cross-coupling reactions of 1,1-dibromoethylenes with alkynylaluminums using the Pd(OAc)-DPPE and Pd(dba)-TFP complexes as catalysts, respectively, has been successfully developed. Though the alkyl substituted conjugated enediynes and unsymmetrical 1,3-diynes were not obtained, this case is also remarkable as the same starting materials could selectively produce either aryl substituted conjugated enediynes or unsymmetrical 1,3-diynes in moderate to excellent yields (up to 99%) in the different Pd-phosphine catalytic systems.
分别使用Pd(OAc)-DPPE和Pd(dba)-TFP配合物作为催化剂，通过1,1-二溴乙烯与炔基铝的选择性交叉偶联反应，成功开发了一种高效合成芳基取代共轭烯二炔和不对称1,3-二炔的方法。虽然未得到烷基取代的共轭烯二炔和不对称1,3-二炔，但这种情况也很显著，因为相同的起始原料在不同的钯-膦催化体系中能够以中等至优异的产率（高达99%）选择性地生成芳基取代的共轭烯二炔或不对称1,3-二炔。
