Rae Eric A, Brown Richard E
Department of Psychology and Neuroscience, Dalhousie University, Halifax, Nova Scotia B3H 4R2, Canada.
Neurosci Biobehav Rev. 2015 Oct;57:238-51. doi: 10.1016/j.neubiorev.2015.09.002. Epub 2015 Sep 6.
The lifespan of mice shows genotype, sex and laboratory effects, but little is known about genotype or sex differences in life expectancy of mouse models of Alzheimer's disease (AD). This paper examines the lifespan of males and females of different mouse models of AD and their wildtype strains. Genotype and sex dependent differences in longevity have important implications for designing experiments with Alzheimer's mouse models, comparing genotype and sex differences in aging mouse models, designing drug treatment regimes and the translation of mouse data to human clinical studies. We conclude that the concept of aging and age-related disorders in mice must be reconsidered based on genotype and sex differences in mouse life expectancy data. Use of concepts such as relative age, prospective lifespan and proportion of lifespan remaining should be included in studies of age-related changes in mouse brains and behavior. Finally, measures such as the Frailty Index, which is independent of chronological age might be used to determine a common scale of aging for all mouse strains.
小鼠的寿命受基因型、性别和实验室条件的影响，但对于阿尔茨海默病（AD）小鼠模型的预期寿命中的基因型或性别差异，我们知之甚少。本文研究了不同AD小鼠模型及其野生型品系的雄性和雌性小鼠的寿命。寿命方面基因型和性别依赖性差异对于设计阿尔茨海默病小鼠模型实验、比较衰老小鼠模型中的基因型和性别差异、设计药物治疗方案以及将小鼠数据转化为人类临床研究具有重要意义。我们得出结论，必须基于小鼠预期寿命数据中的基因型和性别差异，重新审视小鼠衰老及与年龄相关疾病的概念。在研究小鼠大脑和行为的年龄相关变化时，应纳入相对年龄、预期寿命和剩余寿命比例等概念。最后，可以使用诸如衰弱指数等独立于实足年龄的指标来确定所有小鼠品系的共同衰老尺度。
