Schauer U J, Schauer I
Poliklinik für Innere Medizin, Medizinische Akademie, Erfurt, DDR.
Biomed Biochim Acta. 1989;48(10):849-52.
The effects of L-adrenaline and L-noradrenaline on human lecithin: cholesterol acyltransferase (LCAT) activity were investigated in vitro. Both catecholamines are shown to be inhibitors of this enzyme. Despite inter-individual variations in the dose-response relationships calculated for both hormones, significant effects can be expected in the upper physiological range of concentration. Since diminished LCAT activity is known to be followed by a low level of HDL cholesterol and an increased concentration of triglycerides, it is supposed that catecholamine mediated inhibition of LCAT activity may contribute to the development of stress mediated fluctuations in plasma lipoprotein concentrations.
体外研究了L-肾上腺素和L-去甲肾上腺素对人卵磷脂：胆固醇酰基转移酶（LCAT）活性的影响。结果表明，这两种儿茶酚胺都是该酶的抑制剂。尽管两种激素的剂量反应关系存在个体差异，但在生理浓度上限范围内可预期有显著影响。由于已知LCAT活性降低会导致高密度脂蛋白胆固醇水平降低和甘油三酯浓度升高，因此推测儿茶酚胺介导的LCAT活性抑制可能有助于应激介导的血浆脂蛋白浓度波动的发展。
