一种新型波形蛋白衍生抗环瓜氨酸肽抗体（高敏CCP）在类风湿关节炎患者中的诊断性能。
Diagnostic performance of a new vimentin-derived ACPA (CCP high sensitive) in patients with rheumatoid arthritis.
作者信息
Bertin Daniel, Dubucquoi Sylvain, Lakomy Daniela, Deleplancque Anne-Sophie, Desplat-Jégo Sophie
机构信息
Service d'Immunologie, Pôle de Biologie, Hôpital de la Conception, Assistance Publique-Hôpitaux de Marseille, 147, Bd Baille, 13005, Marseille, France.
NICN UMR 7259, Aix-Marseille Université, CNRS, 13916, Marseille, France.
出版信息
Immunol Res. 2016 Apr;64(2):455-60. doi: 10.1007/s12026-015-8690-9.
Autoantibodies are a common feature of rheumatoid arthritis (RA), and their detection is used as a diagnostic tool in medical practice. Rheumatoid factor (RF) and/or anti-citrullinated protein antibodies (ACPA) detection in patients' sera are now included in 2010 ACR/EULAR criteria for RA diagnosis. In this study, we evaluated a new vimentin-derived ACPA ELISA, the anti-cyclic citrullinated peptide high sensitive (CCP hs) test, and we compared its performance with the RF IgM and anti-CCP3 tests on a French multicenter cohort of 84 RA patients, 107 non-RA patients and 100 healthy controls. Sensitivities for RA diagnosis were 71.4, 84.5 and 64.3 % and specificities were 88.4, 86.9 and 87.3 % for CCP hs, CCP3 and RF IgM, respectively. There was a moderate correlation between CCP hs and CCP3 titers (Pearson's r = 0.43; p < 0.0001). These results support the contention that anti-CCP hs antibodies are new reliable ACPA with high specificity for RA.
自身抗体是类风湿性关节炎（RA）的一个常见特征，其检测在医学实践中用作诊断工具。目前，2010年美国风湿病学会（ACR）/欧洲抗风湿病联盟（EULAR）的RA诊断标准纳入了对患者血清中类风湿因子（RF）和/或抗瓜氨酸化蛋白抗体（ACPA）的检测。在本研究中，我们评估了一种新的波形蛋白衍生ACPA酶联免疫吸附测定法（ELISA），即抗环瓜氨酸肽高敏（CCP hs）检测，并在一个由84例RA患者、107例非RA患者和100例健康对照组成的法国多中心队列中，将其性能与RF IgM和抗CCP3检测进行了比较。CCP hs、CCP3和RF IgM对RA诊断的敏感性分别为71.4%、84.5%和64.3%，特异性分别为88.4%、86.9%和87.3%。CCP hs与CCP3滴度之间存在中度相关性（Pearson相关系数r = 0.43；p < 0.0001）。这些结果支持了抗CCP hs抗体是对RA具有高特异性的新型可靠ACPA这一论点。
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