局限于肾小球毛细血管的血管内大B细胞淋巴瘤的特征：一例报告
Characteristics of Intravascular Large B-Cell Lymphoma Limited to the Glomerular Capillaries: A Case Report.
作者信息
Hasegawa Jumpei, Hoshino Junichi, Suwabe Tatsuya, Hayami Noriko, Sumida Keiichi, Mise Koki, Ueno Toshiharu, Sawa Naoki, Wake Atsushi, Ohashi Kenichi, Fujii Takeshi, Honda Kazuho, Takaichi Kenmei, Ubara Yoshifumi
机构信息
Nephrology Center, Toranomon Hospital, Tokyo, Japan ; Department of Nephrology, Ohkubo Hospital, Tokyo, Japan.
Nephrology Center, Toranomon Hospital, Tokyo, Japan.
出版信息
Case Rep Nephrol Dial. 2015 Jul 17;5(2):173-9. doi: 10.1159/000437296. eCollection 2015 May-Aug.
A 65-year-old woman was admitted to our hospital for the evaluation of rapidly progressive renal dysfunction with serum creatinine of 2.7 mg/dl and urinary protein of 1.5 g daily. C-reactive protein (CRP) was 0.1 mg/dl. Kidney-limited intravascular large B-cell lymphoma (IVL) localized to the glomerular capillaries was diagnosed because the intraglomerular cells were positive for CD20 and CD79a, while there was no positivity in the extraglomerular kidney and extrarenal organs. Treatment with rituximab, cyclophosphamide, hydroxydaunomycin, vincristine, and prednisolone was started, and the patient has since been doing well. When IVL is limited to the intraglomerular capillaries, CRP may not be elevated.
一名65岁女性因快速进展性肾功能不全入院，血清肌酐为2.7mg/dl，每日尿蛋白为1.5g。C反应蛋白（CRP）为0.1mg/dl。由于肾小球内细胞CD20和CD79a呈阳性，而肾小球外肾组织和肾外器官无阳性表现，故诊断为局限于肾小球毛细血管的肾脏局限性血管内大B细胞淋巴瘤（IVL）。开始使用利妥昔单抗、环磷酰胺、羟基柔红霉素、长春新碱和泼尼松龙进行治疗，此后患者情况良好。当IVL局限于肾小球毛细血管时，CRP可能不会升高。
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