Quintero Vega Guillermo Enrique, Osorio Daniel, de la Hoz Valle José Antonio, Rodríguez Feria Daniela
Department of Hematology, Hospital Universitario Fundación Santa Fe de Bogotá, Bogotá, Colombia.
Department of Hematology, Universidad de los Andes, Bogotá, Colombia.
Case Rep Oncol Med. 2020 Oct 6;2020:7052536. doi: 10.1155/2020/7052536. eCollection 2020.
Intravascular large B-cell lymphoma (IVLBCL) is a rare subtype of non-Hodgkin lymphoma. It is characterized by the proliferation of cancerous cells into the intraluminal space of the blood vessels. It has a low incidence rate of 0.095 cases per 1,000,000. The clinical presentation is insidious and unspecific, often delaying the diagnosis. IVLBCL can be diagnosed through body images and histopathology analysis. This neoplasm averages a 60% response rate to current chemotherapy treatment, favoring rituximab, and doxorubicin-based regimen if it is diagnosed in time. Here, we present the case of a 56-year-old man admitted to our hospital with a fever who was eventually diagnosed with IVLBCL. He presented to the consultation with anemia, fever, and splenomegaly. An infection panel, a bone marrow biopsy, and a PET-CT scan were performed and ruled out the possibility of infections and neoplasms. The patient later developed edematous syndrome. As a result, a renal biopsy was performed which tested positive for intravascular large B-cell lymphoma. Currently, the patient has been in complete remission for 33 months. Along with presenting this specific case, we also reviewed previously published cases of IVLBCL to illustrate the renal involvement of this pathology.
血管内大B细胞淋巴瘤（IVLBCL）是一种罕见的非霍奇金淋巴瘤亚型。其特征是癌细胞在血管腔内增殖。发病率较低，每100万人中约有0.095例。临床表现隐匿且不具特异性，常导致诊断延迟。IVLBCL可通过身体影像和组织病理学分析进行诊断。这种肿瘤对目前的化疗方案平均有60%的缓解率，若及时诊断，使用利妥昔单抗和基于阿霉素的方案效果较好。在此，我们报告一例56岁男性因发热入院，最终被诊断为IVLBCL的病例。他因贫血、发热和脾肿大前来会诊。进行了感染指标检查、骨髓活检和PET-CT扫描，排除了感染和肿瘤的可能性。患者随后出现水肿综合征。因此，进行了肾活检，结果显示血管内大B细胞淋巴瘤呈阳性。目前，该患者已完全缓解33个月。在呈现这个具体病例的同时，我们还回顾了先前发表的IVLBCL病例，以说明该病理的肾脏受累情况。
