Rahman Fasih Ur, Irfan Muhammad, Fasih Naima, Jabeen Kauser, Sharif Hasanat
Section of Pulmonary and Critical Care Medicine, Department of Medicine, Aga Khan University Hospital, Karachi, Pakistan.
Department of Pathology and Microbiology, Aga Khan University Hospital, Stadium Road, Karachi, 74800, Pakistan.
Infection. 2016 Feb;44(1):127-32. doi: 10.1007/s15010-015-0840-4. Epub 2015 Sep 9.
A case of localized lung scedosporiosis is reported here that mimicked aspergilloma in an immunocompetent host. Through this case the importance of considering Scedosporium spp. in differential diagnosis of locally invasive lung infections and fungal ball is highlighted. As it is difficult to differentiate Scedosporium from Aspergillus on clinical grounds, microscopy, radiology and histopathology, this case is further emphasizing the significance of the definitive etiological characterization of Scedosporium through culture or molecular diagnostic tools. Accurate identification of Scedosporium, surgical resection and high-dose voriconazole has been associated with favorable outcome in most reported cases of scedosporiosis.
本文报告了一例局部肺拟青霉病病例,该病例在免疫功能正常的宿主中表现类似曲菌球。通过该病例,强调了在局部侵袭性肺部感染和真菌球的鉴别诊断中考虑拟青霉属的重要性。由于在临床、显微镜检查、放射学和组织病理学方面难以将拟青霉与曲霉菌区分开来,该病例进一步强调了通过培养或分子诊断工具对拟青霉进行明确病因学鉴定的重要性。在大多数已报道的拟青霉病病例中,准确鉴定拟青霉、手术切除和高剂量伏立康唑与良好预后相关。