错配修复
Mismatch repair.
作者信息
Fishel Richard
机构信息
From the Department of Molecular Virology, Immunology and Medical Genetics, The Ohio State University Wexner Medical Center, Columbus, Ohio 43210 and the Department of Physics and the Biophysics Program, The Ohio State University, Columbus, Ohio 43210
出版信息
J Biol Chem. 2015 Oct 30;290(44):26395-403. doi: 10.1074/jbc.R115.660142. Epub 2015 Sep 9.
Abstract
Highly conserved MutS homologs (MSH) and MutL homologs (MLH/PMS) are the fundamental components of mismatch repair (MMR). After decades of debate, it appears clear that the MSH proteins initiate MMR by recognizing a mismatch and forming multiple extremely stable ATP-bound sliding clamps that diffuse without hydrolysis along the adjacent DNA. The function(s) of MLH/PMS proteins is less clear, although they too bind ATP and are targeted to MMR by MSH sliding clamps. Structural analysis combined with recent real-time single molecule and cellular imaging technologies are providing new and detailed insight into the thermal-driven motions that animate the complete MMR mechanism.
摘要
高度保守的错配修复蛋白MutS同源物（MSH）和MutL同源物（MLH/PMS）是错配修复（MMR）的基本组成部分。经过数十年的争论，现在似乎已经明确，MSH蛋白通过识别错配并形成多个极其稳定的ATP结合滑动夹来启动MMR，这些滑动夹沿相邻DNA扩散而不水解。MLH/PMS蛋白的功能尚不清楚，尽管它们也结合ATP并通过MSH滑动夹靶向MMR。结构分析与最近的实时单分子和细胞成像技术相结合，正在为驱动完整MMR机制的热驱动运动提供新的详细见解。
相似文献
1
Mismatch repair.
J Biol Chem. 2015 Oct 30;290(44):26395-403. doi: 10.1074/jbc.R115.660142. Epub 2015 Sep 9.
2
Cascading MutS and MutL sliding clamps control DNA diffusion to activate mismatch repair.
Nature. 2016 Nov 24;539(7630):583-587. doi: 10.1038/nature20562. Epub 2016 Nov 16.
3
MutS homolog sliding clamps shield the DNA from binding proteins.
J Biol Chem. 2018 Sep 14;293(37):14285-14294. doi: 10.1074/jbc.RA118.002264. Epub 2018 Aug 2.
4
Dynamic control of strand excision during human DNA mismatch repair.
Proc Natl Acad Sci U S A. 2016 Mar 22;113(12):3281-6. doi: 10.1073/pnas.1523748113. Epub 2016 Mar 7.
5
Single-molecule views of MutS on mismatched DNA.
DNA Repair (Amst). 2014 Aug;20:82-93. doi: 10.1016/j.dnarep.2014.02.014. Epub 2014 Mar 12.
6
Stochastic Processes and Component Plasticity Governing DNA Mismatch Repair.
J Mol Biol. 2018 Oct 26;430(22):4456-4468. doi: 10.1016/j.jmb.2018.05.039. Epub 2018 Jun 1.
7
Exploiting the distinctive properties of the bacterial and human MutS homolog sliding clamps on mismatched DNA.
J Biol Chem. 2022 Nov;298(11):102505. doi: 10.1016/j.jbc.2022.102505. Epub 2022 Sep 17.
8
Evidence that hMLH3 functions primarily in meiosis and in hMSH2-hMSH3 mismatch repair.
Cancer Biol Ther. 2009 Jul;8(14):1411-20. doi: 10.4161/cbt.8.14.8886. Epub 2009 Jul 30.
9
MutS functions as a clamp loader by positioning MutL on the DNA during mismatch repair.
Nat Commun. 2022 Oct 3;13(1):5808. doi: 10.1038/s41467-022-33479-3.
10
Recurrent mismatch binding by MutS mobile clamps on DNA localizes repair complexes nearby.
Proc Natl Acad Sci U S A. 2020 Jul 28;117(30):17775-17784. doi: 10.1073/pnas.1918517117. Epub 2020 Jul 15.
引用本文的文献
1
Berberine Sensitises Breast Cancer Cells to Radiation via the Attenuation of DNA Ligase III.
J Cell Mol Med. 2025 Sep;29(17):e70836. doi: 10.1111/jcmm.70836.
2
Tumor irradiation induced immunogenic response: the impact of DNA damage induction and misrepair.
Radiat Oncol. 2025 Aug 21;20(1):133. doi: 10.1186/s13014-025-02711-x.
3
Therapeutic targeting of mismatch repair-deficient cancers.
Nat Rev Clin Oncol. 2025 Jul 10. doi: 10.1038/s41571-025-01054-6.
4
A high-throughput single-molecule platform to study DNA supercoiling effect on protein-DNA interactions.
Nucleic Acids Res. 2025 Jun 20;53(12). doi: 10.1093/nar/gkaf581.
5
Cancer Vulnerabilities Through Targeting the ATR/Chk1 and ATM/Chk2 Axes in the Context of DNA Damage.
Cells. 2025 May 20;14(10):748. doi: 10.3390/cells14100748.
6
Glioblastoma multiforme: an updated overview of temozolomide resistance mechanisms and strategies to overcome resistance.
Discov Oncol. 2025 May 12;16(1):731. doi: 10.1007/s12672-025-02567-3.
7
Case Report: A case of synchronous multiple early gastric cancer with a microsatellite instability-high phenotype.
Front Oncol. 2025 Apr 3;15:1527495. doi: 10.3389/fonc.2025.1527495. eCollection 2025.
8
The structure of the MutL-CTD:processivity-clamp complex provides insight regarding strand discrimination in non-methyl-directed DNA mismatch repair.
Nucleic Acids Res. 2025 Feb 8;53(4). doi: 10.1093/nar/gkaf094.
9
Granulomatous inflammatory responses are elicited in the liver of PD-1 knockout mice by genome mutagenesis.
Discov Immunol. 2024 Dec 25;4(1):kyae018. doi: 10.1093/discim/kyae018. eCollection 2025.
10
Evolving Strategies in the Management of Microsatellite Instability-High/Mismatch Repair Deficient Esophagogastric Adenocarcinoma.
Curr Oncol Rep. 2025 Feb;27(2):81-94. doi: 10.1007/s11912-024-01624-4. Epub 2025 Jan 3.
本文引用的文献
1
Mismatch repair during homologous and homeologous recombination.
Cold Spring Harb Perspect Biol. 2015 Mar 2;7(3):a022657. doi: 10.1101/cshperspect.a022657.
2
Milestones of Lynch syndrome: 1895-2015.
Nat Rev Cancer. 2015 Mar;15(3):181-94. doi: 10.1038/nrc3878. Epub 2015 Feb 12.
3
Lattice light-sheet microscopy: imaging molecules to embryos at high spatiotemporal resolution.
Science. 2014 Oct 24;346(6208):1257998. doi: 10.1126/science.1257998. Epub 2014 Oct 23.
4
PCNA and Msh2-Msh6 activate an Mlh1-Pms1 endonuclease pathway required for Exo1-independent mismatch repair.
Mol Cell. 2014 Jul 17;55(2):291-304. doi: 10.1016/j.molcel.2014.04.034. Epub 2014 Jun 26.
5
A saccharomyces cerevisiae RNase H2 interaction network functions to suppress genome instability.
Mol Cell Biol. 2014 Apr;34(8):1521-34. doi: 10.1128/MCB.00960-13. Epub 2014 Feb 18.
6
Reconstitution of long and short patch mismatch repair reactions using Saccharomyces cerevisiae proteins.
Proc Natl Acad Sci U S A. 2013 Nov 12;110(46):18472-7. doi: 10.1073/pnas.1318971110. Epub 2013 Nov 1.
7
Mutational heterogeneity in cancer and the search for new cancer-associated genes.
Nature. 2013 Jul 11;499(7457):214-218. doi: 10.1038/nature12213. Epub 2013 Jun 16.
8
MutS stimulates the endonuclease activity of MutL in an ATP-hydrolysis-dependent manner.
FEBS J. 2013 Jul;280(14):3467-79. doi: 10.1111/febs.12344. Epub 2013 Jun 18.
9
Ribonucleotides are signals for mismatch repair of leading-strand replication errors.
Mol Cell. 2013 May 9;50(3):437-43. doi: 10.1016/j.molcel.2013.03.017. Epub 2013 Apr 18.
10
Ribonucleotides misincorporated into DNA act as strand-discrimination signals in eukaryotic mismatch repair.
Mol Cell. 2013 May 9;50(3):323-32. doi: 10.1016/j.molcel.2013.03.019. Epub 2013 Apr 18.
Zotero 插件