Babu Ruby P, Christy Alap, Hegde Anupama, Manjrekar Poornima, Joseph Maria
Department of Biochemistry, Kasturba Medical College, Manipal University, Mangalore, Karnataka, India.
Saudi J Kidney Dis Transpl. 2015 Sep;26(5):941-6. doi: 10.4103/1319-2442.164574.
To assess the role of microalbuminuria in pre-eclampsia (PE) as a diagnostic marker, we studied 40 PE cases and 40 normotensive controls at 24 ± 4 weeks of gestation in women 20-35 years of age. The patients with PE had significant microalbuminuria in comparison with the controls, in addition to deranged renal function tests. The receiver operating characteristic curve showed that microalbuminuria had the highest sensitivity (100%) and good specificity (77.6%). Microalbuminuria had the highest area under the curve (0.869) for both diagnosis of PE and renal function assessment. Microalbuminuria also had a good correlation with systolic blood pressure in the cases with mild grades of renal dysfunction. Microalbuminuria is a specific marker in PE and it also helps to assess the renal function status. Therefore, microalbuminuria may be used in the early diagnosis and management of PE patients in order to reduce the immediate and long-term complications.
为评估微量白蛋白尿在子痫前期（PE）中作为诊断标志物的作用，我们研究了40例PE患者和40例血压正常的对照者，这些女性年龄在20至35岁之间，妊娠24±4周。与对照组相比，PE患者除了肾功能检查异常外，还存在显著的微量白蛋白尿。受试者工作特征曲线显示，微量白蛋白尿具有最高的敏感性（100%）和良好的特异性（77.6%）。微量白蛋白尿在PE诊断和肾功能评估方面的曲线下面积最高（0.869）。在轻度肾功能不全的病例中，微量白蛋白尿也与收缩压有良好的相关性。微量白蛋白尿是PE的特异性标志物，它也有助于评估肾功能状态。因此，微量白蛋白尿可用于PE患者的早期诊断和管理，以减少近期和长期并发症。
