Wilke H-J
Institut für Unfallchirurgische Forschung und Biomechanik, Zentrum für Muskuloskelettale Forschung Ulm (ZMFU), Universitätsklinikum Ulm, Helmholtzstr. 14, 89081, Ulm, Deutschland.
Unfallchirurg. 2015 Oct;118(10):822-30. doi: 10.1007/s00113-015-0066-z.
With increasing age, bone mass decreases and the structure of the cancellous bone in the vertebral body changes. Especially in osteoporotic patients, but also with metastases in the vertebral body, this leads to decreased strength and, thus, to an increased risk of vertebral fractures. It is expected that this problem will increase significantly because of demographic developments. To treat or to prevent such vertebral fractures, different augmentation techniques have been developed. They can mainly be divided into vertebroplasty or kyphoplasty procedures.
The goal of this paper is to summarize biomechanical aspects of these augmentations procedures and to present some alternative methods.
With vertebroplasty, the loss of bone mass is balanced by injecting bone cement which improves the failure strength of the affected vertebral body. With kyphoplasty, cavities are created and these are filled with bone cement.
Disadvantages of vertebroplasty are uncontrollable cement extrusion and increased fracture risk in the adjacent vertebral bodies. With balloon kyphoplasty, the adjacent cancellous bone is compacted during dilation and, thus, does not allow good integration with the remaining trabeculae. In addition, this method is associated with an increased risk of fracture in the adjacent vertebrae. To counter these disadvantages, a number of new types of cement and alternative augmentation methods are being developed, with which the vertebral body may be filled or distracted.
The efficacy of these new methods should be tested in appropriate experimental biomechanical studies before they are used in patients.
随着年龄的增长,骨量减少,椎体松质骨结构发生变化。尤其是在骨质疏松患者中,以及椎体发生转移的情况下,这会导致强度降低,进而增加椎体骨折的风险。由于人口结构的发展,预计这个问题将显著增加。为了治疗或预防此类椎体骨折,已经开发了不同的强化技术。它们主要可分为椎体成形术或后凸成形术。
本文的目的是总结这些强化手术的生物力学方面,并介绍一些替代方法。
在椎体成形术中,通过注入骨水泥来平衡骨量的损失,从而提高受影响椎体的破坏强度。在后凸成形术中,要制造空腔并用骨水泥填充。
椎体成形术的缺点是骨水泥挤出不可控以及相邻椎体骨折风险增加。使用球囊后凸成形术时,相邻的松质骨在扩张过程中被压实,因此无法与其余小梁良好融合。此外,这种方法会增加相邻椎体骨折的风险。为了克服这些缺点,正在开发多种新型骨水泥和替代强化方法,通过这些方法可以填充或撑开椎体。
这些新方法的疗效应在适当的实验生物力学研究中进行测试,然后再应用于患者。