Refaat Maged Mohamed, Abdel Rehim Asmaa Saber Mostafa, El-Sayed Hoda Mohammed, Mohamed Nesrine Aly, Khafagy Ahmed Gamal
Department of Internal Medicine, Allergy and Clinical Inmmunology, Ain Shams University, Cairo, Egypt.
Am J Rhinol Allergy. 2015 Sep-Oct;29(5):329-33. doi: 10.2500/ajra.2015.29.4210.
Allergic rhinitis occurs on exposure to a known allergen and is correlated with a positive skin test and physical examination results. Tryptophan is a substrate of many important proteins, e.g., indolamine 2,3 dioxygenase (IDO). IDO, an immunomodulator, is a metabolic enzyme induced by immune activation. It has a significant role in allergic reactions. T-helper 2 cell is proposed to affect the expression of IDO.
To evaluate IDO levels in patients with allergic rhinitis compared with controls and its relationship to the severity of allergic rhinitis.
This case-control study included 20 patients who were atopic and with allergic rhinitis who attended the allergy clinic of Ain Shams University Hospitals. Twenty age- and sex-matched patients who were not atopic were included as controls. An allergic rhinitis diagnosis was made according to the Allergic Rhinitis and its Impact on Asthma document. Complete history taking, physical examination, skin-prick test, complete blood cell count, erythrocyte sedimentation rate, total serum immunoglobulin E (IgE), IDO concentration, and nasal smear for eosinophils were done for the patients.
There was a significant increase in IDO levels in allergic rhinitis in comparison with subjects without allergy (p < 0.001). IDO was positively correlated with total IgE levels (p < 0.037). There was an insignificant relationship among IDO levels and age, sex, duration of the disease, severity score, nasal and blood eosinophilia, and number of positive allergens.
IDO plays an important role in patients with atopic symptomatic allergic rhinitis, especially with increased levels of IgE. There is no relationship between IDO levels and severity of disease.
变应性鼻炎在接触已知变应原时发生，与皮肤试验阳性及体格检查结果相关。色氨酸是许多重要蛋白质的底物，如吲哚胺2,3-双加氧酶（IDO）。IDO作为一种免疫调节剂，是一种由免疫激活诱导的代谢酶。它在过敏反应中起重要作用。有研究提出辅助性T2细胞会影响IDO的表达。
评估变应性鼻炎患者与对照组相比的IDO水平及其与变应性鼻炎严重程度的关系。
本病例对照研究纳入了20例患有特应性疾病且有变应性鼻炎的患者，这些患者在艾因夏姆斯大学医院过敏门诊就诊。另外纳入20例年龄和性别匹配的非特应性患者作为对照。根据《变应性鼻炎及其对哮喘的影响》文件进行变应性鼻炎的诊断。对患者进行了完整的病史采集、体格检查、皮肤点刺试验、全血细胞计数、红细胞沉降率、血清总免疫球蛋白E（IgE）、IDO浓度检测以及鼻嗜酸性粒细胞涂片检查。
与无过敏的受试者相比，变应性鼻炎患者的IDO水平显著升高（p < 0.001）。IDO与总IgE水平呈正相关（p < 0.037）。IDO水平与年龄、性别、病程、严重程度评分、鼻和血嗜酸性粒细胞增多以及阳性变应原数量之间的关系不显著。
IDO在特应性症状性变应性鼻炎患者中起重要作用，尤其是在IgE水平升高时。IDO水平与疾病严重程度之间无关联。
