癌症免疫疗法的突破。
Releasing the Brakes on Cancer Immunotherapy.
机构信息
Molecular Pathogenesis Program, The Kimmel Center for Biology and Medicine of the Skirball Institute, New York University School of Medicine, New York, NY 10016, USA; The Howard Hughes Medical Institute.
出版信息
Cell. 2015 Sep 10;162(6):1186-90. doi: 10.1016/j.cell.2015.08.038.
PMID:26359975
Abstract
This year's Lasker∼DeBakey Clinical Research Award goes to James Allison for discovering that antibody blockade of the T cell molecule CTLA-4 unleashes the body's immune response against malignant tumors. This has led to development of multiple "immune checkpoint therapies" that are prolonging and saving the lives of thousands of cancer patients.
摘要
今年的拉斯克-德贝基临床医学研究奖授予詹姆斯·艾利森，以表彰他发现抗体阻断 T 细胞分子 CTLA-4 会释放身体的免疫反应对抗恶性肿瘤。这导致了多种“免疫检查点疗法”的发展，这些疗法延长和挽救了数千名癌症患者的生命。
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