Cohen Carl I, Meesters Paul D, Zhao Jingna
SUNY Downstate Medical Center, Brooklyn, NY, USA.
Department of Psychiatry, VU University Medical Center, GGZ inGeest and EMGO+, Institute for Health and Care Research, Amsterdam, Netherlands.
Lancet Psychiatry. 2015 Apr;2(4):340-50. doi: 10.1016/S2215-0366(15)00003-6. Epub 2015 Mar 31.
Worldwide, in the past few decades, the demographics of older people (ie, people 55 years and over) with schizophrenia have changed completely with respect to absolute numbers of people affected, the proportion of all people with the disorder, life expectancy, and residential status. The ageing schizophrenia population has created vast health-care needs and their medical comorbidity contributes to higher mortality than in the general population. Proposals to classify schizophrenia into early-onset, late-onset, and very-late-onset subtypes now should be tempered by the recognition that comorbid medical and neurological disorders can contribute to psychotic symptoms in later life. The concept of outcome has become more nuanced with an appreciation that various outcomes can occur, largely independent of each other, that need different treatment approaches. Data show that schizophrenia in later life is not a stable end-state but one of fluctuation in symptoms and level of functioning, and show that pathways to improvement and recovery exist. Several novel non-pharmacological treatment strategies have been devised that can augment the clinical options used to address the specific needs of older adults with schizophrenia.
在全球范围内,在过去几十年里,老年精神分裂症患者(即55岁及以上人群)在受影响人数的绝对数量、该疾病患者在总人口中的比例、预期寿命和居住状况方面都发生了彻底变化。老龄化的精神分裂症患者群体产生了巨大的医疗保健需求,他们的合并症导致其死亡率高于普通人群。现在,将精神分裂症分为早发型、晚发型和极晚发型亚型的提议,应因认识到合并的医学和神经疾病可能导致晚年出现精神症状而有所缓和。随着认识到各种结果可能在很大程度上相互独立地出现,需要不同的治疗方法,结果的概念变得更加细致入微。数据表明,晚年精神分裂症并非稳定的终末状态,而是症状和功能水平波动的状态之一,并且表明存在改善和康复的途径。已经设计出了几种新颖的非药物治疗策略,这些策略可以增加用于满足老年精神分裂症患者特定需求的临床选择。
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