[维拉帕米对肺心病合并心力衰竭患者肺动脉压的影响]
[Effects of verapamil on pulmonary arterial pressure in patients with cor pulmonale complicated by heart failure].
作者信息
Shan Z Y
出版信息
Zhonghua Jie He He Hu Xi Za Zhi. 1989 Dec;12(6):340-2, 381.
In this study, observation of the effects of verapamil on pulmonary arterial pressure and on treating right heart failure were done in 15 patients with chronic cor pulmonale complicated with heart failure using monitoring of hemodynamic changes by right cardiac catheter. The results showed that verapamil had remarkable effect on pulmonary arterial pressure. With no significant effect on systemic blood pressure, verapamil decreases right ventricular systolic pressure by 1.3 kPa (9.6 mmHg), pulmonary arterial systolic pressure by 1.5 kPa (11 mmHg) and mean pulmonary arterial pressure by 1.1 kPa (8.5 mmHg). Verapamil is clinically useful by decreasing cardiac afterload, improving cardiac function, treating right heart failure and relieving bronchial spasm.
本研究采用右心导管监测血流动力学变化，对15例慢性肺心病合并心力衰竭患者观察了维拉帕米对肺动脉压及治疗右心衰竭的效果。结果显示，维拉帕米对肺动脉压有显著效果。在对体循环血压无显著影响的情况下，维拉帕米使右心室收缩压降低1.3 kPa（9.6 mmHg），肺动脉收缩压降低1.5 kPa（11 mmHg），平均肺动脉压降低1.1 kPa（8.5 mmHg）。维拉帕米通过降低心脏后负荷、改善心功能、治疗右心衰竭及缓解支气管痉挛，在临床上具有应用价值。
Zotero 插件