Ge C W, Li D G, Hao Y M
Zhonghua Nei Ke Za Zhi. 1989 Dec;28(12):731-3, 768.
30 cases of chronic myeloid leukemia (CML) with non-myeloid blast crisis from 1966 to 1986 in PUMC Hospital were investigated. Morphologically 18 cases were lymphoblastic, 4 histiocytic, 3 basophilic, 2 erythro-leukemic, 2 megakaryocytic, and 1 monocytic, the ratio between male and female was 3.3:1, and their age ranged from 16 to 55 years. These results suggest that blast crisis of CML may involve many other cellular derivatives than the myeloid series of the pluripotential stem cells, Spleen was not palpable among half of the patients with lymphoblastic crisis, but all the cases with blast crisis of other morphological types had enlarged lives and spleen, especially those with histiocytic and monocytic crisis of CML. Most of cases of CML with non-myeloid blast crisis had poor prognosis with survival time of less than 6 months. However, cases of CML with lymphoblastic crisis had longer survival duration than those with non-myeloid blast crisis of other types.
对1966年至1986年期间在北京协和医院就诊的30例慢性髓性白血病（CML）非髓系原始细胞危象患者进行了调查。形态学上，18例为淋巴细胞性，4例为组织细胞性，3例为嗜碱性，2例为红白血病，2例为巨核细胞性，1例为单核细胞性，男女比例为3.3:1，年龄在16至55岁之间。这些结果表明，CML的原始细胞危象可能涉及多能干细胞髓系以外的许多其他细胞衍生物。淋巴细胞危象患者中有一半触不到脾脏，但其他形态类型原始细胞危象的所有病例肝脏和脾脏均肿大，尤其是CML组织细胞性和单核细胞性危象患者。大多数非髓系原始细胞危象的CML患者预后较差，生存时间不到6个月。然而，淋巴细胞危象的CML患者生存时间比其他类型非髓系原始细胞危象的患者长。
