Phillips S M, Catanzaro P J, Carpenter C B, Zweiman B
Immunopharmacology. 1979 Jul;1(4):277-99. doi: 10.1016/0162-3109(79)90026-2.
The effect of 6-mercaptopurine on the development and expression of delayed hypersensitivity was studied in the guinea pig. Results indicated that 6-MP produced its suppressive effects primarily by action on cells of the monocyte-macrophage series. Suppression could occur under conditions of both developing and pre-established delayed hypersensitivity. The defect primarily involved newly synthesized, bone marrow-derived monocytes. Marked alterations in monocyte macrophage generation and distribution, especially the T1/2 of circulating monocytes were demonstrated. Suppressive effects were associated with the appearance of a unique morphologic microscopy. Finally, the in vivo expression of delayed hypersensitivity correlated better with a variety of parameters relating to qualitative macrophage function and distribution rather than those relating to quantitative macrophage levels.
研究了6-巯基嘌呤对豚鼠迟发型超敏反应的发生和表达的影响。结果表明，6-巯基嘌呤主要通过作用于单核细胞-巨噬细胞系列细胞产生抑制作用。在迟发型超敏反应的发生和预先建立的条件下均可发生抑制作用。缺陷主要涉及新合成的、骨髓来源的单核细胞。单核细胞巨噬细胞的生成和分布出现明显改变，尤其是循环单核细胞的半衰期。抑制作用与一种独特的形态学显微镜表现有关。最后，迟发型超敏反应的体内表达与多种与巨噬细胞定性功能和分布相关的参数相关性更好，而不是与巨噬细胞定量水平相关的参数。
