WWTR1（含WW结构域的转录调节因子1）。
WWTR1 (WW domain containing transcription regulator 1).
作者信息
Zhao Yulei, Yang Xiaolong
机构信息
Department of Pathology and Molecular Medicine, Queen's University, Kingston, ON, Canada.
出版信息
Atlas Genet Cytogenet Oncol Haematol. 2014 Nov 1;18(11):849-852. doi: 10.4267/2042/54169.
WWTR1 (also called TAZ in publications. Therefore, TAZ is used in the following description) is a WW domaing-containing transcriptional coactivator, which was first identified as a 14-3-3 binding protein. TAZ is the downstream component in the Hippo pathway, and also has been found to interact with different pathways, such as Wnt, TGFbeta, etc. TAZ is involved in mesenchymal stem cell differentiation as well as tumorigenesis. High level of TAZ has been found in different cancers, such as breast cancer, colon cancer, lung cancer, etc.
WWTR1（在出版物中也称为TAZ。因此，在以下描述中使用TAZ）是一种含WW结构域的转录共激活因子，最初被鉴定为一种14-3-3结合蛋白。TAZ是Hippo通路的下游成分，还被发现与不同通路相互作用，如Wnt、TGFβ等。TAZ参与间充质干细胞分化以及肿瘤发生。在不同癌症中发现了高水平的TAZ，如乳腺癌、结肠癌、肺癌等。
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