辛伐他汀在2型糖尿病患者中的应用：对氧化应激的影响。
Simvastatin Use in Patients with Type 2 Diabetes Mellitus: The Effects on Oxidative Stress.
作者信息
Hadi Najah R, Abdelhussein Mohammad A, Rudha Ammar R M, Jamil Dina A, Al-Aubaidy Hayder A
机构信息
Department of Pharmacology, Kufa University, Najaf, Iraq.
Department of Medicine, Kufa University, Najaf, Iraq.
出版信息
Oman Med J. 2015 Jul;30(4):237-40. doi: 10.5001/omj.2015.49.
OBJECTIVES
Studies have shown that people with type 2 diabetes mellitus (T2DM) may develop atherosclerosis due to the disturbance in oxidative control and progressive dyslipidemia. Our study aimed to highlight the benefits of simvastatin treatment in improving serum lipids and reducing oxidative damage in patients with T2DM.
METHODS
Our randomized control trial included 56 patients with T2DM and dyslipidemia. The participants were on glibenclamide (5mg/day) during the period of the study. The patients were divided into two study groups (groups 1 and 2). Group 1 was the control group and consisted of 31 patients. Group 2 consisted of 25 participants, who were given simvastatin 20mg tablet once daily for 12 weeks. The control group did not receive simvastatin. Both groups were followed-up for measurement of blood pressure, pulse rate, serum lipids, and parameters of oxidative stress.
RESULTS
The simvastatin treated group showed a significant improvement with reduced erythrocyte glutathione compared to the control group (p<0.001). This was also associated with a significant reduction in erythrocyte malondialdehyde in the simvastatin treated group compared to the control group (p<0.001). Serum lipids reflected a similar improvement in the levels of erythrocyte malondialdehyde.
CONCLUSION
Our study highlights the beneficial role of simvastatin in improving the degree of oxidative stress in patients with T2DM through its effects on serum lipids and lipid peroxidation.
目的
研究表明，2型糖尿病（T2DM）患者可能由于氧化控制紊乱和进行性血脂异常而发生动脉粥样硬化。我们的研究旨在强调辛伐他汀治疗在改善T2DM患者血脂和减少氧化损伤方面的益处。
方法
我们的随机对照试验纳入了56例T2DM合并血脂异常患者。在研究期间，参与者服用格列本脲（5mg/天）。患者被分为两个研究组（1组和2组）。1组为对照组，由31例患者组成。2组由25名参与者组成，他们每天服用一次20mg辛伐他汀片，共12周。对照组未接受辛伐他汀治疗。两组均进行随访，以测量血压、脉搏率、血脂和氧化应激参数。
结果
与对照组相比，辛伐他汀治疗组红细胞谷胱甘肽降低，有显著改善（p<0.001）。与对照组相比，辛伐他汀治疗组红细胞丙二醛也显著降低（p<0.001）。血脂水平的变化与红细胞丙二醛水平的改善相似。
结论
我们的研究强调了辛伐他汀通过对血脂和脂质过氧化的作用，在改善T2DM患者氧化应激程度方面的有益作用。
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