Al-Aubaidy Hayder A, Jelinek Herbert F
Redox Rep. 2014 Mar;19(2):87-91. doi: 10.1179/1351000213Y.0000000080. Epub 2014 Jan 13.
The role of triglycerides in early preclinical atherosclerosis is controversial. Antioxidant markers may be associated with triglyceride levels in early preclinical atherosclerosis especially when fasting plasma glucose is raised.
This cross-sectional study included 127 participants attending the Diabetes Screening Clinic, Charles Sturt University, Australia.
Serum 8-hydroxy-2-deoxy-guanosine (8-OHdG) was significantly greater in the impaired fasting glucose (IFG) group compared with the control group (536.7 pg/ml ± 249.8 versus 171.4 pg/ml ± 96.9, respectively). The increase in 8-OHdG was associated with a mildly non-significant elevation in low-density lipoprotein level (3.2 ± 1.1 mmol/l) and a poor level of high-density lipoprotein (1.31 ± 0.3 mmol/l) in the IFG group. However, a significant increase in triglycerides (1.6 ± 0.97 mmol/l; P < 0.05) in the IFG group was observed. Erythrocyte reduced glutathione (GSH) levels in the IFG group, although increased, were also not significantly different to control.
A significant increase in 8-OHdG is associated with increased levels of triglycerides in the absence of significant changes in reduced GSH and normal levels of cholesterol in the IFG cohort, suggesting that oxidative stress may be present and indicative of subclinical atherosclerosis.
甘油三酯在临床前期动脉粥样硬化早期阶段的作用存在争议。抗氧化标志物可能与临床前期动脉粥样硬化早期阶段的甘油三酯水平相关，尤其是在空腹血糖升高时。
这项横断面研究纳入了127名前往澳大利亚查尔斯特大学糖尿病筛查诊所就诊的参与者。
空腹血糖受损（IFG）组的血清8-羟基-2-脱氧鸟苷（8-OHdG）水平显著高于对照组（分别为536.7 pg/ml±249.8与171.4 pg/ml±96.9）。IFG组中8-OHdG的升高与低密度脂蛋白水平轻度非显著性升高（3.2±1.1 mmol/l）以及高密度脂蛋白水平较差（1.31±0.3 mmol/l）相关。然而，观察到IFG组甘油三酯显著升高（1.6±0.97 mmol/l；P<0.05）。IFG组红细胞还原型谷胱甘肽（GSH）水平虽有所升高，但与对照组相比也无显著差异。
在IFG队列中，8-OHdG显著升高与甘油三酯水平升高相关，而还原型GSH无显著变化且胆固醇水平正常，这表明可能存在氧化应激并提示亚临床动脉粥样硬化。
