Lai Tzu-Hsien, Protsenko Ekaterina, Cheng Yu-Chen, Loggia Marco L, Coppola Gianluca, Chen Wei-Ta
Department of Neurology, National Yang-Ming University School of Medicine, Taipei 112, Taiwan ; Section of Neurology, Department of Internal Medicine, Far Eastern Memorial Hospital, New Taipei City 220, Taiwan.
MGH/MIT/HMS Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA.
Neural Plast. 2015;2015:205985. doi: 10.1155/2015/205985. Epub 2015 Aug 20.
Headaches are universal experiences and among the most common disorders. While headache may be physiological in the acute setting, it can become a pathological and persistent condition. The mechanisms underlying the transition from episodic to chronic pain have been the subject of intense study. Using physiological and imaging methods, researchers have identified a number of different forms of neural plasticity associated with migraine and other headaches, including peripheral and central sensitization, and alterations in the endogenous mechanisms of pain modulation. While these changes have been proposed to contribute to headache and pain chronification, some findings are likely the results of repetitive noxious stimulation, such as atrophy of brain areas involved in pain perception and modulation. In this review, we provide a narrative overview of recent advances on the neuroimaging, electrophysiological and genetic aspects of neural plasticity associated with the most common forms of chronic headaches, including migraine, cluster headache, tension-type headache, and medication overuse headache.
头痛是普遍存在的体验，也是最常见的病症之一。虽然头痛在急性情况下可能是生理性的，但它可能会演变成病理性的持续性病症。从发作性疼痛转变为慢性疼痛的潜在机制一直是深入研究的主题。通过生理和成像方法，研究人员已经确定了许多与偏头痛和其他头痛相关的不同形式的神经可塑性，包括外周和中枢敏化，以及疼痛调节内源性机制的改变。虽然这些变化被认为与头痛和疼痛慢性化有关，但一些发现可能是重复性有害刺激的结果，例如参与疼痛感知和调节的脑区萎缩。在这篇综述中，我们对与最常见的慢性头痛形式相关的神经可塑性的神经影像学、电生理学和遗传学方面的最新进展进行了叙述性概述，这些慢性头痛包括偏头痛、丛集性头痛、紧张型头痛和药物过量使用性头痛。
