通过靶向肿瘤干细胞标志物双皮质素样激酶1（DCLK1）、Musashi 1（MSI1）、富含亮氨酸重复序列G蛋白偶联受体5（LGR5）和多梳蛋白抑制复合物2核心蛋白BMI1的试剂对微小RNA（miRNA）的调控
Regulation of miRNAs by agents targeting the tumor stem cell markers DCLK1, MSI1, LGR5, and BMI1.
作者信息
Sureban Sripathi M, Qu Dongfeng, Houchen Courtney W
机构信息
Department of Internal Medicine, University of Oklahoma Health Science Center, Oklahoma City, OK 73104 ; Department of Veterans Affairs Medical Center, Oklahoma City, OK 73104 ; Peggy and Charles Stephenson Oklahoma Cancer Center, Oklahoma City, OK 73104 Phone number: (405) 271-2175/fax number: (405) 271-5450.
出版信息
Curr Pharmacol Rep. 2015 Aug 1;1(4):217-222. doi: 10.1007/s40495-014-0006-6.
Abstract
Gastrointestinal cancers such as colorectal, pancreatic, liver, gastric, and esophageal, are the most common forms of malignant cancers. MicroRNAs (miRNA) play important role in regulating gastrointestinal cancer progress either as potent oncogenes or tumor suppressors. In this report, we will discuss the importance of several tumor suppressors involved in colon or pancreatic cancer. Some recent studies on tumor stem cells and regulation of these miRNAs via agents targeting the tumor stem cell markers doublecortin-like kinase 1 (DCLK1), Musashi-1 (MSI1), polycomb protein BMI1, and WNT genes (LGR5 and ASCL2) will also be discussed. Agents such as siRNA/shRNA, small molecule kinase inhibitors, and general herbal drugs (curcumin) targeting these tumor stem cell markers and tumor suppressor miRNAs could be the perfect therapeutic agents for the treatment of these cancers.
摘要
胃肠道癌症，如结直肠癌、胰腺癌、肝癌、胃癌和食管癌，是最常见的恶性肿瘤形式。微小RNA（miRNA）作为强效癌基因或肿瘤抑制因子，在调节胃肠道癌症进展中发挥重要作用。在本报告中，我们将讨论几种参与结肠癌或胰腺癌的肿瘤抑制因子的重要性。还将讨论一些最近关于肿瘤干细胞以及通过靶向肿瘤干细胞标志物双皮质素样激酶1（DCLK1）、Musashi-1（MSI1）、多梳蛋白BMI1和WNT基因（LGR5和ASCL2）的药物对这些miRNA的调控的研究。诸如靶向这些肿瘤干细胞标志物和肿瘤抑制性miRNA的小干扰RNA/短发夹RNA、小分子激酶抑制剂和普通草药（姜黄素）等药物可能是治疗这些癌症的理想治疗药物。
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本文引用的文献
1
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Mol Cancer. 2014 May 6;13:103. doi: 10.1186/1476-4598-13-103.
2
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Cancer Lett. 2014 Aug 28;351(1):151-61. doi: 10.1016/j.canlet.2014.05.011. Epub 2014 May 28.
3
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