Centre for Biomimetic Sensor Science, School of Materials Science and Engineering, Nanyang Technological University, 50 Nanyang Drive, Singapore 637553.
Nanoscale. 2015 Nov 7;7(41):17244-8. doi: 10.1039/c5nr03373j.
Localized surface plasmon resonance (LSPR) biosensors typically suffer from diffusion limited mass transport and nonspecific adsorption upon detection of biomolecules in real biofluids. We employ here a peptide-modified plasmonic gold nanohole (AuNH) array for real-time detection of human troponin I (cTnI). Applying a negative electric bias on the AuNH sensor chip enables us to attract and concentrate cTnI at the sensor surface, while repelling other proteins thus decreasing interferences due to nonspecific adsorption.
局部表面等离子体共振（LSPR）生物传感器在检测真实生物流体中的生物分子时，通常受到扩散限制的传质和非特异性吸附的影响。在这里，我们采用肽修饰的等离子体金纳米孔（AuNH）阵列实时检测人心肌肌钙蛋白 I（cTnI）。在 AuNH 传感器芯片上施加负偏压，使我们能够将 cTnI 吸引并浓缩在传感器表面，同时排斥其他蛋白质，从而减少由于非特异性吸附引起的干扰。
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