Biasco G, Paganelli G M, Brillanti S, Lalli A A, Brandi G, Terranova A, Miglioli M, Barbara L
Acta Gastroenterol Belg. 1989 May-Aug;52(3-4):361-6.
We examined cell proliferation kinetics of gastric mucosa in 28 patients affected by chronic atrophic gastritis by means of autohistoradiography of biopsies incubated with tritiated thymidine. The results have been compared with those obtained from 12 patients with normal gastric mucosa. In chronic atrophic gastritis, patients showed a proliferative pattern similar to controls. The remaining patients had an increased number of replicating cells together with an expansion of the proliferative compartment towards the surface of the mucosa. These results suggest that in chronic atrophic gastritis, as far as cell proliferation is concerned, two subgroups of patients with two different levels of risk of developing gastric cancer exist. The first one, showing an expansion of the proliferating area, probably is at higher risk. As a matter of fact, such an abnormality expresses an alteration of cell growth control similar to that observed in preneoplastic conditions of the colon and in gastric mucosa of animals treated with carcinogenic substances.
我们通过对用氚标记胸腺嘧啶核苷孵育的活检组织进行自动放射自显影，研究了28例慢性萎缩性胃炎患者胃黏膜的细胞增殖动力学。并将结果与12例胃黏膜正常的患者所得结果进行了比较。在慢性萎缩性胃炎患者中，其增殖模式与对照组相似。其余患者复制细胞数量增加，同时增殖区向黏膜表面扩展。这些结果表明，就细胞增殖而言，慢性萎缩性胃炎患者存在两个不同胃癌发生风险水平的亚组。第一个亚组增殖区域扩大，可能处于较高风险。事实上，这种异常表现出与在结肠肿瘤前状态以及用致癌物质处理过的动物胃黏膜中观察到的相似的细胞生长控制改变。
