一种用于亚硫酸盐的快速响应荧光探针及其生物成像

A fast-responsive fluorescent probe for sulfite and its bioimaging.

作者信息

Wang Jiaoliang, Long Liping, Xiao Xiaoming

机构信息

College of Chemistry and Environment Engineering, Hunan City University, Yiyang, Hunan, People's Republic of China.

College of Chemistry and Chemical Engineering, University of South China, Hengyang, Hunan, People's Republic of China.

出版信息

Luminescence. 2016 May;31(3):775-81. doi: 10.1002/bio.3023. Epub 2015 Sep 17.

DOI:10.1002/bio.3023

PMID:26377341

Abstract

A turn-on fluorescent probe Coumarin-SO2 based on a nucleophilic addition reaction was developed for the rapid detection of SO3(2-) in aqueous media. The probe Coumarin-SO2 displays excellent water solubility, fast response, highly sensitivity and highly selectivity over other biological related species. More importantly, living cell imaging experiments indicate the feasibility of using the probe for the detection of SO3(2-) in biological systems.

摘要

基于亲核加成反应开发了一种用于在水性介质中快速检测SO₃²⁻的荧光开启型探针香豆素-SO₂。探针香豆素-SO₂具有出色的水溶性、快速响应、高灵敏度以及对其他生物相关物种的高选择性。更重要的是，活细胞成像实验表明了使用该探针在生物系统中检测SO₃²⁻的可行性。