Polyzoidis Stavros, Koletsa Triantafyllia, Panagiotidou Smaro, Ashkan Keyoumars, Theoharides Theoharis C
Department of Neurosurgery, Kings College London, London, UK.
Department of Pathology, AHEPA General Hospital, Thessaloniki, Greece.
J Neuroinflammation. 2015 Sep 17;12:170. doi: 10.1186/s12974-015-0388-3.
Research focus in neuro-oncology has shifted in the last decades towards the exploration of tumor infiltration by a variety of immune cells and their products. T cells, macrophages, B cells, and mast cells (MCs) have been identified.
A systematic review of the literature was conducted by searching PubMed, EMBASE, Google Scholar, and Turning Research into Practice (TRIP) for the presence of MCs in meningiomas using the terms meningioma, inflammation and mast cells.
MCs have been detected in various tumors of the central nervous system (CNS), such as gliomas, including glioblastoma multiforme, hemangioblastomas, and meningiomas as well as metastatic brain tumors. MCs were present in as many as 90 % of all high-grade meningiomas mainly found in the perivascular areas of the tumor. A correlation between peritumoral edema and MCs was found.
Accumulation of MCs in meningiomas could contribute to the aggressiveness of tumors and to brain inflammation that may be involved in the pathogenesis of additional disorders.
在过去几十年中，神经肿瘤学的研究重点已转向探索各种免疫细胞及其产物对肿瘤的浸润情况。已鉴定出T细胞、巨噬细胞、B细胞和肥大细胞（MCs）。
通过在PubMed、EMBASE、谷歌学术和将研究转化为实践（TRIP）中搜索，使用“脑膜瘤”“炎症”和“肥大细胞”等术语，对脑膜瘤中MCs的存在情况进行文献系统综述。
在中枢神经系统（CNS）的各种肿瘤中已检测到MCs，如胶质瘤，包括多形性胶质母细胞瘤、血管母细胞瘤、脑膜瘤以及转移性脑肿瘤。在所有高级别脑膜瘤中，多达90%存在MCs，主要见于肿瘤的血管周围区域。发现肿瘤周围水肿与MCs之间存在相关性。
脑膜瘤中MCs的积聚可能导致肿瘤的侵袭性以及可能参与其他疾病发病机制的脑部炎症。
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