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采用左胸廓内动脉和桡动脉T型移植物进行全动脉血运重建的长期随访:生存率、心脏发病率和生活质量。

Long-term follow-up of total arterial revascularization with left internal thoracic artery and radial artery T-grafts: survival, cardiac morbidity and quality of life.

作者信息

Fleissner Felix, Engelke Hendrick, Rojas-Hernandez Sebastian, Ismail Issam, Stiefel Penelope, Cebotari Serghei, Haverich Axel, Shrestha Malakh, Martens Andreas

机构信息

Clinic for Cardiac, Thoracic, Transplantation and Vascular Surgery, Hannover Medical School, Hannover, Germany

Clinic for Cardiac, Thoracic, Transplantation and Vascular Surgery, Hannover Medical School, Hannover, Germany.

出版信息

Eur J Cardiothorac Surg. 2016 Apr;49(4):1195-200. doi: 10.1093/ejcts/ezv289. Epub 2015 Sep 15.

Abstract

OBJECTIVES

Coronary artery bypass grafting is the gold standard for the treatment of patients with multiple-vessel coronary artery disease. The long-term outcome can be improved using arterial grafts. We analysed the initial series of patients who underwent total arterial revascularization at our institute using left internal thoracic artery (LITA) and radial artery (RA) composite T-grafts and had a follow-up of >10 years.

METHODS

We included all patients who received an isolated, non-emergent total arterial revascularization using LITA-RA T-grafts between September 1996 and August 2001 in our institution. We performed a follow-up of 138 patients (104 male, 60 ± 9 years old).

RESULTS

Early outcome was excellent. The 30-day mortality, reoperation, neurological complication and myocardial ischaemia rate was 1% (n = 2), 5% (n = 7), 2% (n = 3) and 2% (n = 3), respectively. Mean follow-up was 11 ± 3 years. Long-term survival was 79% (n = 86). There were seven cardiac deaths during follow-up. Freedom from major cardiovascular events for 1, 5 and 10 years was 97, 91 and 84%, respectively. A total of 95 coronary angiographies were performed 4.6 ± 4.1 years postoperatively. In total, 453 anastomoses using the composite graft (LITA-RA as T-graft) were performed. During follow-up, 35 anastomoses were occluded (30 RA anastomoses and 5 LITA anastomoses), leading to an occlusion rate of 7.7% during follow-up. Percutaneous coronary intervention was performed in 18 cases and coronary reoperation in two cases during follow-up. Quality-of-life assessment by Minnesota Living with Heart Failure Questionnaire revealed excellent results.

CONCLUSIONS

Total arterial revascularization using composite LITA-RA T-grafts leads to excellent long-term results after >10 years.

摘要

目的

冠状动脉搭桥术是治疗多支冠状动脉疾病患者的金标准。使用动脉移植物可改善长期预后。我们分析了在我院接受全动脉血运重建术的首批患者系列,这些患者采用左内乳动脉(LITA)和桡动脉(RA)复合T型移植物,且随访时间超过10年。

方法

我们纳入了1996年9月至2001年8月在我院接受使用LITA-RA T型移植物进行孤立性、非急诊全动脉血运重建术的所有患者。我们对138例患者(104例男性,年龄60±9岁)进行了随访。

结果

早期预后良好。30天死亡率、再次手术率、神经系统并发症率和心肌缺血率分别为1%(n = 2)、5%(n = 7)、2%(n = 3)和2%(n = 3)。平均随访时间为11±3年。长期生存率为79%(n = 86)。随访期间有7例心源性死亡。1年、5年和10年无重大心血管事件的发生率分别为97%、91%和84%。术后4.6±4.1年共进行了95次冠状动脉造影。总共进行了453次使用复合移植物(LITA-RA作为T型移植物)的吻合术。随访期间,35次吻合口闭塞(30次RA吻合口和5次LITA吻合口),随访期间闭塞率为7.7%。随访期间18例患者接受了经皮冠状动脉介入治疗,2例患者接受了冠状动脉再次手术。通过明尼苏达心力衰竭生活问卷进行的生活质量评估显示结果良好。

结论

使用复合LITA-RA T型移植物进行全动脉血运重建术在10年以上可带来优异的长期结果。

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