早期静脉推注羟考酮或芬太尼对腹腔镜胆囊切除术后全身麻醉苏醒及术后镇痛的效果：一项随机试验
Efficacy of early intravenous bolus oxycodone or fentanyl in emergence from general anaesthesia and postoperative analgesia following laparoscopic cholecystectomy: A randomized trial.
作者信息
Choi Yoon-Ji, Park Sang-Wook, Kwon Hyun-Jung, Choi Jae-Moon, Lee Yu-Mi
机构信息
Department of Dental Anaesthesiology, Seoul National University Dental Hospital, Seoul, Republic of Korea.
Department of Anaesthesiology and Pain Medicine, University of Ulsan College of Medicine, Asan Medical Centre, Seoul, Republic of Korea.
出版信息
J Int Med Res. 2015 Dec;43(6):809-18. doi: 10.1177/0300060515594194. Epub 2015 Sep 16.
OBJECTIVES
To compare prospectively the efficacy of early intravenous bolus of oxycodone or fentanyl in providing analgesia at emergence from general anaesthesia following laparoscopic cholecystectomy.
METHODS
Patients were randomly assigned to receive either 0.08 mg/kg oxycodone (Group O) or 1 µg/kg fentanyl (Group F), 20 min before the end of surgery. Postoperative pain was evaluated using a visual analogue scale (VAS). The time to first postoperative analgesic dose, requirement for analgesia and side-effects were assessed in the postanaesthesia care unit (PACU).
RESULTS
The VAS scores at 0 min and 30 min and requirement for analgesia were significantly lower in Group O (n = 28) than in Group F (n = 26). The time to first analgesia dose was significantly longer in Group O than Group F. There were no significant between-group differences in the incidence of side-effects.
CONCLUSIONS
Oxycodone relieves immediate postoperative pain significantly better than fentanyl, and is not associated with an increase in side-effects in patients undergoing laparoscopic cholecystectomy.
目的
前瞻性比较在腹腔镜胆囊切除术后全身麻醉苏醒期早期静脉推注羟考酮或芬太尼的镇痛效果。
方法
患者在手术结束前20分钟被随机分配接受0.08mg/kg羟考酮（O组）或1μg/kg芬太尼（F组）。术后疼痛采用视觉模拟评分法（VAS）进行评估。在麻醉后护理单元（PACU）评估首次术后镇痛剂量的时间、镇痛需求和副作用。
结果
O组（n = 28）在0分钟和30分钟时的VAS评分以及镇痛需求显著低于F组（n = 26）。O组首次镇痛剂量的时间显著长于F组。两组间副作用发生率无显著差异。
结论
羟考酮在缓解腹腔镜胆囊切除术后即刻疼痛方面明显优于芬太尼，且与副作用增加无关。
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