Horwitz D, Margolius H S, Keiser H R
J Clin Endocrinol Metab. 1978 Aug;47(2):296-9. doi: 10.1210/jcem-47-2-296.
Urinary excretion of kallikrein by 16 normal and 8 hypertensive subjects was studied at three levels of dietary potassium: 85 meq/day for 5 days, 185 meq/day for 7 days, and 25 meq/day for 10 days. Excretion of kallikrein varied directly with potassium intake and paralleled excretion of aldosterone in both normotensive and hypertensive subjects. Mean levels of excretion of kallikrein at 85, 185, and 25 meq intake of potassium were 10.8, 19.1, and 5.8 esterase U/day (EU/day), respectively, for the normotensive subjects and 8.8, 13.9, and 6.1 EU/day for the hypertensive subjects. Mean levels of excretion of kallikrein were significantly higher in white that in black subjects among normals and hypertensives [13.0 vs. 5.9 EU/day for normals (P less than 0.05) and 13.7 vs. 4.0 EU/day for hypertensives (P less than 0.05) on the 85 meq/day diet]. The parallel changes in excretion of kallikrein and aldosterone support the hypothesis that changes in effective levels of aldosterone induce changes in the excretion of kallikrein. Because of racial differences in excretion of kallikrein, matched groups should be used for comparisons of the kallikrein system in disease states.
对16名正常人和8名高血压患者在三种饮食钾水平下的尿激肽释放酶排泄情况进行了研究：85毫当量/天，持续5天；185毫当量/天，持续7天；25毫当量/天，持续10天。在正常血压和高血压受试者中，激肽释放酶的排泄量与钾摄入量直接相关，且与醛固酮的排泄情况平行。正常血压受试者在钾摄入量为85、185和25毫当量时，激肽释放酶的平均排泄水平分别为10.8、19.1和5.8酯酶单位/天（EU/天），高血压受试者分别为8.8、13.9和6.1 EU/天。在正常人和高血压患者中，白人激肽释放酶的平均排泄水平显著高于黑人[在85毫当量/天的饮食中，正常人为13.0 vs. 5.9 EU/天（P<0.05），高血压患者为13.7 vs. 4.0 EU/天（P<0.05）]。激肽释放酶和醛固酮排泄的平行变化支持了醛固酮有效水平的变化诱导激肽释放酶排泄变化的假说。由于激肽释放酶排泄存在种族差异，在疾病状态下比较激肽释放酶系统时应使用匹配的组。
