上海崇明成年人中房颤与连接蛋白40及1型血管紧张素II受体基因多态性的关联
Association of atrial fibrillation with gene polymorphisms of connexin 40 and angiotensin II receptor type 1 in Chongming adults of Shanghai.
作者信息
Hou Shuxin, Lu Yingmin, Huang Damin, Luo Xiaohan, Yue Dongmei, Zhang Jinchun
机构信息
Department of Cardiology, Xinhua (Chongming) Hospital Affiliated to Shanghai Jiao Tong University School of Medicine Shanghai 202150, China.
出版信息
Int J Clin Exp Med. 2015 Jul 15;8(7):11803-10. eCollection 2015.
OBJECTIVE
To characterized the gene polymorphisms of connexin 40 (cx40) and angiotensin II receptor type 1 (AT1R) in Chongming adults with atrial fibrillation (AF) and to explore their relationships with AF.
METHODS
82 patients with AF, and 82 subjects without AF were enrolled. Polymorphisms of cx40 G-44A and AT1 A1166C were detected. Moreover, several samples were randomly selected to validate the gene polymorphisms of cx40 and AT1.
RESULTS
Genotypes AA, AG and GG of cx40 G-44A were found in both AF patients and controls. The frequencies of genotypes AA, AG and GG were 39%, 29% and 32%, respectively, in AF patients and 31%, 35% and 34%, respectively in controls. The frequencies of alleles A and G were 54% and 46%, respectively in AF patients and 48% and 52%, respectively, in controls (P < 0.05). The risk for AF in patients with allele A increased 1.31 times (OR = 1.31, P < 0.05). The frequencies of genotypes AA, AC and CC were 88%, 8% and 4%, respectively in AF patients and 93%, 6% and 1%, respectively in controls. The frequencies of alleles A and C were 92% and 8%, respectively in AF patients and 96% and 4%, respectively in controls (P < 0.05). More AF patients had allele C as compared to controls. The risk for AF increased by 1.43 times in patients with allele C (OR = 1.43, P < 0.05).
CONCLUSION
There were relationships between gene polymorphisms of cx40 and AT1 and AF in Chongming adults. Allele A of cx40 G-44A and allele C of AT1 A1166C significantly increase the risk for AF.
目的
对崇明地区成年心房颤动（AF）患者的连接蛋白40（cx40）和血管紧张素II 1型受体（AT1R）基因多态性进行特征分析，并探讨它们与心房颤动的关系。
方法
纳入82例心房颤动患者和82例非心房颤动受试者。检测cx40 G-44A和AT1 A1166C的多态性。此外，随机选择若干样本验证cx40和AT1的基因多态性。
结果
在心房颤动患者和对照组中均发现了cx40 G-44A的AA、AG和GG基因型。AA、AG和GG基因型频率在心房颤动患者中分别为39%、29%和32%，在对照组中分别为31%、35%和34%。等位基因A和G的频率在心房颤动患者中分别为54%和46%，在对照组中分别为48%和52%（P<0.05）。携带等位基因A的患者发生心房颤动的风险增加1.31倍（OR=1.31，P<0.05）。AA、AC和CC基因型频率在心房颤动患者中分别为88%、8%和4%，在对照组中分别为93%、6%和1%。等位基因A和C的频率在心房颤动患者中分别为92%和8%，在对照组中分别为96%和4%（P<0.05）。与对照组相比，更多的心房颤动患者携带等位基因C。携带等位基因C的患者发生心房颤动的风险增加1.43倍（OR=1.43，P<0.05）。
结论
崇明地区成年人心房颤动与cx40和AT1基因多态性之间存在关联。cx40 G-44A的等位基因A和AT1 A1166C的等位基因C显著增加心房颤动风险。
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