Elbir Haitham, FotsoFotso Aurélien, Diatta Georges, Trape Jean François, Arnathau Céline, Renaud François, Durand Patrick
Aix Marseille, Université, Unité de Recherche sur les Maladies Infectieuses et Tropicales Emergentes (URMITE), UMR CNRS 7278, IRD 198, INSERM 1095, Marseille, France.
Campus commun UCAD-IRD d'Hann, Dakar, Senegal.
Parasit Vectors. 2015 Sep 17;8:477. doi: 10.1186/s13071-015-1089-6.
In West Africa, tick-borne relapsing fever is a neglected arthropod-borne infection caused by Borrelia crocidurae transmitted by the argasid tick Ornithodoros sonrai. From an epidemiological point of view, it is of interest to know whether some genotypes of the vector are specialized in carrying certain genotypes of the pathogen.
Thirty-five O. sonrai ticks collected in Mali, Senegal, Mauritania and Morocco confirmed to be B. crocidurae-infected, were genotyped by 16S rRNA gene sequencing. B. crocidurae was genotyped by Multispacer Sequence Typing. The 35 O. sonrai ticks grouped into 12 genotypes with strong geographical structuration. MST resolved the 35 B. crocidurae isolates into 29 genotypes with pairwise divergence of 0.09 - 1.56 % without strict geographical structuration as genotype ST22 was found in Mali, Senegal and Mauritania. There was no evidence of tick-borrelia specialization as one O. sonrai genotype carried several B. crocidurae genotypes and one B. crocidurae genotype was found in different O. sonrai genotypes.
This report illustrates a non-specialized circulation of B. crocidurae borreliae within O. sonrai ticks in West Africa.
在西非，蜱传回归热是一种被忽视的节肢动物传播感染病，由钝缘蜱属的桑氏钝缘蜱传播的克罗诺蜱传疏螺旋体引起。从流行病学角度来看，了解媒介的某些基因型是否专门携带病原体的某些基因型是很有意义的。
在马里、塞内加尔、毛里塔尼亚和摩洛哥采集的35只经证实感染了克罗诺蜱传疏螺旋体的桑氏钝缘蜱，通过16S rRNA基因测序进行基因分型。通过多间隔序列分型对克罗诺蜱传疏螺旋体进行基因分型。这35只桑氏钝缘蜱分为12个基因型，具有很强的地理结构。多间隔序列分型将35株克罗诺蜱传疏螺旋体分离株分为29个基因型，两两差异为0.09%-1.56%，没有严格的地理结构，因为在马里、塞内加尔和毛里塔尼亚都发现了基因型ST22。没有证据表明蜱与疏螺旋体存在特异性关系，因为一种桑氏钝缘蜱基因型携带几种克罗诺蜱传疏螺旋体基因型，且在不同的桑氏钝缘蜱基因型中发现了一种克罗诺蜱传疏螺旋体基因型。
本报告说明了克罗诺蜱传疏螺旋体在西非桑氏钝缘蜱中是非特异性传播的。
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