Gravet Claire, Roquet Laurence, Rioux-Leclercq Nathalie, Marguet Florent, Sabourin Jean-Christophe
Service d'anatomie et cytologie pathologiques, CHU de Rouen, 1, rue de Germont, 76000 Rouen, France.
Service d'anatomie et cytologie pathologiques, CHU de Rouen, 1, rue de Germont, 76000 Rouen, France.
Ann Pathol. 2015 Oct;35(5):440-4. doi: 10.1016/j.annpat.2015.05.021. Epub 2015 Sep 14.
Glomus tumors are rare mesenchymal tumors, mostly cutaneous or subcutaneous, for which visceral locations have been described. We report the case of a solid renal glomus tumor incidentally discovered in a 60-year-old patient. The tumor was 25mm wide and was mainly composed of glomus cells expressing smooth muscle actin and vimentin. These cells were negative for cytokeratin, neuroendocrine markers and renin. Glomus cells were associated with blood vessels and bundles of smooth muscle fibers. The purpose of this work is to report the diagnostic criteria, signs of malignancy and main differential diagnosis of these rare tumors whose prognosis is usually excellent after complete surgical resection.
球旁细胞瘤是一种罕见的间叶组织肿瘤,多位于皮肤或皮下,也有发生于内脏的报道。我们报告一例60岁患者偶然发现的实性肾球旁细胞瘤。肿瘤直径25mm,主要由表达平滑肌肌动蛋白和波形蛋白的球旁细胞组成。这些细胞细胞角蛋白、神经内分泌标志物和肾素均为阴性。球旁细胞与血管和平滑肌纤维束相关。本文旨在报告这些罕见肿瘤的诊断标准、恶性征象及主要鉴别诊断,此类肿瘤完整手术切除后预后通常良好。