简短通讯：中国流行的主要HIV-1亚型中，Gp120潜在N-糖基化位点的分布存在差异。

Short Communication: The Distribution of Potential N-Linked Glycosylation Sites in Gp120 Differs Among Major HIV-1 Subtypes Circulating in China.

作者信息

Shi Yin, Feng Yanmeng, Ding Xiangqing, Chen Jian, Xu Jianqing, Wan Yanmin

机构信息

1 Shanghai Public Health Clinical Center, Fudan University , Shanghai, China .

2 Wenzhou Medical University , Wenzhou, China .

出版信息

AIDS Res Hum Retroviruses. 2016 Jan;32(1):101-8. doi: 10.1089/aid.2015.0193. Epub 2015 Sep 18.

DOI:10.1089/aid.2015.0193

PMID:26384088

Abstract

CRF01_AE shows an obvious sexual transmission advantage over other major HIV-1 subtypes circulating in China. Previous studies showed that the presence or absence of potential N-linked glycosylation sites (PNGSs) in variable loops might affect HIV-1 transmission; it is therefore of interest to compare the distribution of potential PNGSs on envelopes of different subtypes circulating in China. Compared to CRF07_BC, CRF08_BC, B, and B' subtypes isolated in China, CRF01_AE subtypes isolated from both China and outside China had significantly fewer PNGSs in total and in V2/V4, while they had significantly more PNGSs in V5. HIV-1 subtype CRF01_AE has a unique PNGS distribution pattern in Gp120, which may contribute to its advantage in sexual transmission in China.

摘要

CRF01_AE在中国流行的其他主要HIV-1亚型中显示出明显的性传播优势。先前的研究表明，可变环中潜在N-糖基化位点（PNGSs）的存在与否可能会影响HIV-1的传播；因此，比较中国流行的不同亚型包膜上潜在PNGSs的分布情况很有意义。与在中国分离的CRF07_BC、CRF08_BC、B和B'亚型相比，在中国和国外分离的CRF01_AE亚型在总体和V2/V4区域的PNGSs明显更少，而在V5区域则明显更多。HIV-1 CRF01_AE亚型在Gp120中有独特的PNGS分布模式，这可能有助于其在中国性传播方面的优势。