Department of Obstetrics, Gynecology, and Reproductive Biology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA Boston Center for Endometriosis, Boston Children's Hospital and Brigham and Women's Hospital, Boston, MA, USA Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA
Hum Reprod. 2015 Oct;30(10):2252-3. doi: 10.1093/humrep/dev206.
In this issue of Human Reproduction, a debate article presents a charge to balance effectiveness and safety in Reproductive Medicine. This debate contribution applauds the dialogue opened and constructive opinions that are presented. However, several additional issues are suggested for consideration. Safety must be more broadly considered beyond the achievement of a healthy singleton pregnancy, with reproductive medicine a unique field that has the potential to impact the health and wellbeing of multiple people at one time. Many fields have grappled with the need to balance effective treatment with unintended harms, and reproductive medicine should capitalize upon that body of literature. Finally, to maximize both efficacy and safety in reproductive medicine, there is no replacement for the conduct of well powered, rigorously designed, highly generalizable, multidisciplinary studies.
在本期《人类生殖》中，一篇辩论文章提出了在生殖医学中平衡有效性和安全性的问题。这篇辩论文章赞扬了所提出的对话和建设性意见。然而，还提出了其他一些需要考虑的问题。安全性必须更广泛地考虑，而不仅仅是实现健康的单胎妊娠，生殖医学是一个独特的领域，有可能同时影响多人的健康和幸福。许多领域都在努力平衡有效的治疗和意外的伤害，生殖医学应该利用这方面的文献。最后，为了在生殖医学中最大限度地提高疗效和安全性，没有任何替代方法可以替代进行有力、精心设计、高度可推广、多学科研究。
