Sobieszek A
Acta Neurobiol Exp (Wars). 1989;49(6):337-57.
The formation and subsequent development of after-discharges (ADs) and spontaneous interictal spikes was investigated in a group of ten kindled cats. The electrodes used for electrical stimulation and EEG recording were located in various parts of the hippocampal formation: in the hippocampal gyrus, dentate gyrus, subiculum and entorhinal cortex. The animals were stimulated once daily with 1 s trains of 50/s electric pulses. The choice of stimulating electrodes, stimulating currents and, in some cases, monitoring of the stability of stimulating conditions was aided by recording hippocampal field potentials evoked by intrahippocampal electrical stimulation. A subgroup of 5 cats was stimulated at AD threshold or near threshold currents of constant intensity. The following patterns of AD development were observed: (i) a long lasting initial phase of stable, a few second-long ADs with subsequent development, culminating in prolonged ADs and complex partial or secondary generalized tonic clonic seizures, after 80-120 days of kindling; (ii) stable pattern of brief ADs (0.3-1.5 s duration) during 120 days of kindling; (iii) gradual development of initially brief ADs (about 5 s) into longer lasting ADs (about 35 s) associated with complex partial seizures, during 220 days of stimulation. Spontaneous interictal spikes developed in this subgroup after 16-15 days of kindling. The second subgroup of 5 animals was subjected to stimulation with gradually increasing AD subthreshold currents. In two animals of this subgroup spontaneous EEG discharges of isolated spikes and clusters of high frequency spikes appeared in the stimulated hippocampal gyrus after 10 days of kindling. Apart from the diversity of after-discharge development patterns the results indicate relative independence of the processes underlying formation of the spontaneous interictal spikes and after-discharges.
在一组十只点燃猫中研究了后放电（ADs）和自发性发作间期棘波的形成及随后的发展。用于电刺激和脑电图记录的电极位于海马结构的不同部位：海马回、齿状回、下托和内嗅皮质。每天用1秒的50次/秒电脉冲串刺激动物一次。通过记录海马内电刺激诱发的海马场电位，辅助选择刺激电极、刺激电流，以及在某些情况下监测刺激条件的稳定性。5只猫的亚组在AD阈值或恒定强度的接近阈值电流下进行刺激。观察到以下AD发展模式：（i）在点燃80 - 120天后，有一个持续较长时间的初始阶段，AD稳定，持续几秒，随后发展，最终演变为延长的AD和复杂部分性或继发性全身性强直阵挛发作；（ii）在点燃120天期间，短暂AD（持续时间0.3 - 1.5秒）的稳定模式；（iii）在刺激220天期间，最初短暂的AD（约5秒）逐渐发展为与复杂部分性发作相关的持续时间更长的AD（约35秒）。在该亚组中，点燃16 - 15天后出现自发性发作间期棘波。第二组5只动物用逐渐增加的低于AD阈值的电流进行刺激。在该亚组的两只动物中，点燃10天后，在受刺激的海马回中出现了孤立棘波和高频棘波簇的自发性脑电图放电。除了后放电发展模式的多样性外，结果表明自发性发作间期棘波和后放电形成过程相对独立。
