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双胎反向动脉灌注序列征(TRAP):一例病例报告及治疗综述

Twin Reversed Arterial Perfusion (TRAP) Sequence: A Case Report and Review of Treatment.

作者信息

Nanthakomon Tongta, Chanthasenanont Athita, Somprasit Charintip, Manusook Sakol, Pongrojpaw Densak, Suwannarurk Komsun

出版信息

J Med Assoc Thai. 2015 Apr;98 Suppl 3:S132-40.

Abstract

A cardiac twin or twin reversed arterial perfusion (TRAP) sequence is a rare unique complication of monozygotic multiple pregnancy. In this disorder, there is a normally formed donor (the pump twin) who has features of congestive heart failure (CHF) as well as a recipient (the acardiac twin) who lacks a well-defined a heart structure. Also evident are other structures, namely the TRAP sequencefrom pump to acardiacfetus via single artery-to-artery and vein-to-vein anastomoses directly between the two cords or indirectly on the chorionic plate. Overall, the perinatal mortality rate for the pump twin is 35-55%. Prenatal diagnosis and prognosis factors can be examined through ultrasound. The optimal management of a cardiac twin pregnancies is controversial. The expected treatment of acardiac anomaly presently relies on maximizing the chance ofterm delivery and preventing CHF in the healthy pump twin or interrupting vascularization between the two twins. This article reported the experience of acardiac twin management in Thammasat University Hospital and reviewed the current knowledge ofthe condition, prenatal diagnosis, prognosis factor and management options focusing on conservative management compared to invasive treatment.

摘要

无心双胎或双胎反向动脉灌注(TRAP)序列是单卵多胎妊娠罕见的独特并发症。在这种疾病中,有一个正常形成的供体(泵血双胎),其具有充血性心力衰竭(CHF)的特征,还有一个受体(无心双胎),其缺乏明确的心脏结构。同样明显的是其他结构,即通过单条动脉与动脉、静脉与静脉的吻合,在两条脐带之间直接或在绒毛膜板上间接从泵血胎儿到无心胎儿的TRAP序列。总体而言,泵血双胎的围产期死亡率为35%至55%。产前诊断和预后因素可通过超声检查。无心双胎妊娠的最佳管理存在争议。目前,对无心畸形的预期治疗依赖于最大化足月分娩的机会,预防健康泵血双胎发生CHF,或中断两个双胎之间的血管形成。本文报告了泰国国立法政大学医院对无心双胎的管理经验,并回顾了目前对该疾病的认识、产前诊断、预后因素以及侧重于保守治疗与侵入性治疗比较的管理选择。

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