Rockoff A S, Christy D, Zeldis N, Tsai D J, Kramer R A
Pediatrics. 1978 Jan;61(1):73-6.
A 4-year-old girl with hemoglobin SC disease died following general anesthesia. Autopsy showed widespread intravascular sickling; staining with hematoxylin-basic fuchsin-picric acid demonstrated newly developed massive myocardial necrosis, a rarely documented finding. Anesthesia may produce conditions that provoke "crises" in patients with sickle hemoglobinopathies. Preoperative identification of sickle states and careful attention to hydration and oxygenation may minimize anesthetic risks in these patients.
一名患有血红蛋白SC病的4岁女孩在全身麻醉后死亡。尸检显示广泛的血管内镰状化；苏木精-碱性品红-苦味酸染色显示新出现的大量心肌坏死，这是一个鲜有记录的发现。麻醉可能会产生引发镰状细胞血红蛋白病患者“危机”的情况。术前识别镰状状态并密切关注补液和氧合可将这些患者的麻醉风险降至最低。
