Rolland A-L, Dewailly D
Service de gynécologie endocrinienne et médecine de la reproduction, hôpital Jeanne-de-Flandre, avenue Eugène-Avinée, 59037 Lille, France.
Service de gynécologie endocrinienne et médecine de la reproduction, hôpital Jeanne-de-Flandre, avenue Eugène-Avinée, 59037 Lille, France.
Gynecol Obstet Fertil. 2015 Oct;43(10):670-5. doi: 10.1016/j.gyobfe.2015.08.004. Epub 2015 Sep 19.
In women, the anti-Müllerian hormone (AMH) is secreted by the granulosa cells of growing follicles. Its measurement is strongly correlated with antral follicle count and represents a reliable marker of ovarian reserve. It also has the advantage of being highly reproducible since it has little variation within and between cycles. However, although it seems to be a good quantitative reflection of the ovarian reserve, it does not assess the oocyte quality. This drawback precludes any good prediction of female fertility in the general population. However, the AMH assay can become an indirect marker of female fertility in some situations at risk for premature ovarian failure or in the polycystic ovary syndrome. Its interest is no more to be proven in assisted reproductive technology where it is a valuable aid to the choice of the proposed techniques, ovarian stimulation protocols and gonadotropin doses. AMH is finally very informative in monitoring cancer patients having received ovariotoxic drugs or having undergone mutilating ovarian surgeries. In conclusion, although it cannot be considered itself as a reliable predictor of pregnancy in women, AMH is now a must in the management and treatment of female infertility.
在女性中，抗苗勒管激素（AMH）由生长卵泡的颗粒细胞分泌。其测量值与窦卵泡计数密切相关，是卵巢储备的可靠标志物。它还具有高度可重复性的优点，因为在一个周期内以及不同周期之间变化很小。然而，尽管它似乎是卵巢储备的良好定量反映，但它并不能评估卵母细胞质量。这一缺点使得无法对普通人群的女性生育能力进行良好预测。然而，在某些有卵巢早衰风险的情况或多囊卵巢综合征中，AMH检测可成为女性生育能力的间接标志物。在辅助生殖技术中，它对所提议技术的选择、卵巢刺激方案和促性腺激素剂量具有重要帮助，其价值已无需再证明。最后，AMH在监测接受过卵巢毒性药物治疗或接受过毁损性卵巢手术的癌症患者方面也非常有用。总之，尽管AMH本身不能被视为女性妊娠的可靠预测指标，但它现在是女性不孕症管理和治疗中必不可少的一项检测。
