Bjerring P
Department of Dermatology, Marselisborg Hospital, Aarhus, Denmark.
Skin Pharmacol. 1989;2(4):210-6. doi: 10.1159/000210822.
A double-blind, randomized, placebo-controlled comparison of the analgesic and antihistaminic effects of four commonly used antihistamines (terfenadine, antazoline, diphenhydramine and cimetidine) was performed. Wheal and flare areas after histamine skin prick and sensory and pain thresholds induced by cutaneous argon laser irradiation were determined. Terfenadine, antazoline and diphenhydramine significantly reduced wheal and flare after histamine skin pricks. Only diphenhydramine increased the pain threshold to noxious cutaneous laser stimulations (22%) with a concomitant reduction of histamine wheal (61.5%) and flare (52.8%). The sensory threshold was not affected significantly. The antihistaminic and analgesic effects were not related.
进行了一项双盲、随机、安慰剂对照试验，比较四种常用抗组胺药（特非那定、安他唑啉、苯海拉明和西咪替丁）的镇痛和抗组胺作用。测定了组胺皮肤点刺后的风团和红晕面积以及皮肤氩激光照射诱导的感觉和疼痛阈值。特非那定、安他唑啉和苯海拉明显著减少组胺皮肤点刺后的风团和红晕。只有苯海拉明提高了对有害皮肤激光刺激的疼痛阈值（22%），同时组胺风团减少（61.5%），红晕减少（52.8%）。感觉阈值未受到显著影响。抗组胺作用和镇痛作用无关。
