Silva Fernanda C, de Menezes Rodrigo C, Chianca Deoclécio A
Laboratory of Cardiovascular Physiology, Department of Biological Sciences, Institute of Biological Sciences, Federal University of Ouro Preto Ouro Preto, Brazil ; Graduate Program in Biological Sciences - CBIOL/NUPEB, Federal University of Ouro Preto Ouro Preto, Brazil.
Front Physiol. 2015 Sep 2;6:246. doi: 10.3389/fphys.2015.00246. eCollection 2015.
The malnutrition in early life is associated with metabolic changes and cardiovascular impairment in adulthood. Deficient protein intake-mediated hypertension has been observed in clinical and experimental studies. In rats, protein malnutrition also increases the blood pressure and enhances heart rate and sympathetic activity. In this review, we discuss the effects of post-weaning protein malnutrition on the resting mean arterial pressure and heart rate and their variabilities, cardiovascular reflexes sensitivity, cardiac autonomic balance, sympathetic and renin-angiotensin activities and neural plasticity during adult life. These insights reveal an interesting prospect on the autonomic modulation underlying the cardiovascular imbalance and provide relevant information on preventing cardiovascular diseases.
生命早期的营养不良与成年期的代谢变化和心血管功能损害有关。临床和实验研究中均观察到蛋白质摄入不足介导的高血压。在大鼠中，蛋白质营养不良也会升高血压、加快心率并增强交感神经活动。在本综述中，我们讨论了断奶后蛋白质营养不良对成年期静息平均动脉压、心率及其变异性、心血管反射敏感性、心脏自主神经平衡、交感神经和肾素-血管紧张素活性以及神经可塑性的影响。这些见解揭示了心血管失衡背后自主神经调节的有趣前景，并为预防心血管疾病提供了相关信息。
