Thorat Ashok, Jeng Long-Bin, Yang Horng-Ren, Li Ping-Chun, Li Ming-Li, Yeh Chun-Chieh, Chen Te-Hung, Hsu Shih-Chao, Poon Kin-Shing
Organ Transplantation Center, China Medical University Hospital, Taichung, Taiwan.
Departments of Surgery, China Medical University Hospital, Taichung, Taiwan.
Liver Transpl. 2016 Feb;22(2):192-200. doi: 10.1002/lt.24342.
Outflow reconstruction in living donor liver transplantation (LDLT) is certainly difficult in limited retrohepatic space with using right liver grafts with venous anomalies. Venoplasty of the inferior right hepatic veins (IRHVs) and middle hepatic vein (MHV) reconstruction using synthetic grafts to form a common outflow channel or a second venocaval anastomosis are available options. We aim to compare outcomes of LDLT recipients who underwent outflow reconstruction with a "V-Plasty" technique and outcomes of patients who underwent a second venocaval anastomosis. Out of 325 recipients who underwent LDLT from March 2011 to September 2014, 45 received right liver allografts that were devoid of MHV with multiple draining IRHVs (2 or more). Group A (n = 16) comprised the recipients with outflow reconstruction with a V-Plasty, and group B (n = 29) included the recipients with a second venocaval anastomosis. Group A recipients (male:female, 10:6; median age, 50.5 years) had a mean Model for End-Stage Liver Disease score of 14.7, whereas for group B recipients (male:female, 20:9; median age, 52.0 years) it was 17.2. The mean IRHV diameter for group A and B grafts was 8.3 mm each. Mean warm ischemia time for group A was significantly lower (25.2 minutes) as compared to group B recipients (34.6 minutes) with P < 0.001. The 2-month patency rates of vascular grafts were 100% for group A recipients with no evidence of thrombosis. In conclusion, the V-Plasty technique of MHV and IRHV reconstruction to form a common outflow is a new concept that proves to be a safe and feasible alternative for second venocaval anastomosis.
在活体肝移植(LDLT)中,利用存在静脉异常的右肝移植物在有限的肝后间隙进行流出道重建无疑具有挑战性。使用合成移植物对右下肝静脉(IRHVs)进行静脉成形术以及重建肝中静脉(MHV)以形成共同流出道或进行第二次腔静脉吻合是可行的选择。我们旨在比较采用“V形整形术”技术进行流出道重建的LDLT受者的结局与接受第二次腔静脉吻合术的患者的结局。在2011年3月至2014年9月接受LDLT的325例受者中,45例接受了无MHV且有多个引流IRHVs(2个或更多)的右肝同种异体移植物。A组(n = 16)包括采用V形整形术进行流出道重建的受者,B组(n = 29)包括接受第二次腔静脉吻合术的受者。A组受者(男∶女为10∶6;中位年龄50.5岁)的终末期肝病模型平均评分为14.7,而B组受者(男∶女为20∶9;中位年龄52.0岁)为17.2。A组和B组移植物的IRHV平均直径均为8.3 mm。A组的平均热缺血时间(25.2分钟)显著低于B组受者(34.6分钟),P < 0.001。A组受者血管移植物的2个月通畅率为100%,无血栓形成迹象。总之,通过MHV和IRHV重建形成共同流出道的V形整形术是一个新概念,被证明是第二次腔静脉吻合术的一种安全可行的替代方法。